Roche
Principal Bioinformatics Scientist I
Mississauga · Principal
Sponsorship not specifiedDetected 8 days ago
PythonC++BashGitDockerCI/CDLinuxData AnalysisStatisticsComplianceStakeholder ManagementBioinformaticsNGSResearchCommunicationCollaborationAdaptability
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About the role
- As a member of this team, you will sit at the dynamic intersection of computational biology, assay development, and software engineering to translate complex genomic data into actionable health insights.
- AI-Accelerated Engineering: Routinely integrate AI coding tools and automated workflows to accelerate algorithm development, refactoring, and data analysis.
- Production Translation: Draft clear functional and technical specifications to guide software engineering teams in transitioning research prototypes into robust clinical software.
Responsibilities
- As a Bioinformatics Scientist, you will lead the design, optimization, and clinical validation of innovative NGS data processing pipelines and algorithms.
- Analytical Validation: Partner with Assay Development and CLIA lab teams to establish statistical analysis plans and validate novel diagnostic assays (ensuring high sensitivity, specificity, and precision).
- Quality & Regulatory Compliance: Implement sample- and run-level statistical QC metrics while maintaining thorough QMS-compliant documentation for CAP/CLIA audits.
- This role is a vital part of our Bioinformatics team, which is committed to advancing precision medicine by building cutting-edge computational tools for clinical diagnostics.
- Design, benchmark, and optimize scalable, reproducible NGS bioinformatics pipelines using Nextflow, Docker/Singularity, and cloud environments.
- Partner with Assay Development and CLIA lab teams to establish statistical analysis plans and validate novel diagnostic assays (ensuring high sensitivity, specificity, and precision).
- Implement sample- and run-level statistical QC metrics while maintaining thorough QMS-compliant documentation for CAP/CLIA audits.
Requirements
- OR Ph.D. with 4+ years of related experience (work experience can be prior or post-grad
- Clinical Diagnostic Expertise: Demonstrated track record supporting or working within a CAP/CLIA-certified laboratory environment with direct experience in diagnostic test development and analytical validation.
- Proficient in Python/R/C++ and Linux/Bash alongside hands-on experience using workflow managers (Nextflow) and containerized software deployments.
Compensation
- The expected salary range for this position based on the primary location of Mississauga is 115,328.00 and 151,368.00 of hiring range.
Benefits
- This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come.
Company info
- A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.
- Let's build a healthier future, together.
- Roche is an Equal Opportunity Employer.
- A healthier future drives us to innovate.
- Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come.
- Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products.
- We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.
- Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.
This listing is sourced directly from Roche's careers page and normalized into a canonical job model.