Twist Bioscience
Sr. Staff Scientist - Protein Sciences R&D
USA - South San Francisco, CA · Staff+
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About the role
- You will start as an individual contributor, personally executing and improving core workflows, while simultaneously defining the technical roadmap.
- Twist Bioscience Corporation is an Equal Opportunity Employer.
Responsibilities
- Develop small- and medium-scale antibody production workflows, including various formats (single-chain, IgG, multi-specific), culture systems, and purification methods
- Improve all aspects of the end-to-end antibody development workflow: construct design, cell line development, cell culture, purification, and analytics
- Build from the ground up and manage a team of scientists and RAs that will aid you in your work
- Independently design and execute experiments, and analyze experimental data
- Move projects forward efficiently / manage time and resources effectively / prioritize tasks in accordance with the company's goals
- Document and communicate results clearly and succinctly
- Demonstrated ability to build, improve, and standardize antibody generation workflows, not just execute existing SOPs.
Requirements
- 8+ years of experience in protein sciences
- Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.
- Proven experience with bispecific antibody architectures, including but not limited to:
- Hands-on experience with antibody characterization methods, such as:
- PhD in Cell Biology, Biochemistry, or a closely related field
- Hands-on experience working with antibody expression and purification
Nice to have
- Strong understanding of transient vs stable expression tradeoffs and when to deploy each during platform development.
- Experience improving expression yields and product quality through sequence, vector, and host engineering.
- Strong understanding of platform robustness, reproducibility, and cost drivers.
- Experience generating and optimizing stable mammalian cell lines (CHO preferred):
- Clone screening, productivity optimization, and stability assessment
- Experience with liquid-handling systems and automation is a plus
- Familiarity with Python or equivalent programming languages is a plus
Compensation
- San Francisco Bay Area Pay Range
Company info
- Deep hands-on experience designing, expressing, and optimizing monoclonal antibodies, with demonstrated understanding of Fc structure-function relationships (effector function, stability, manufacturability).
- Knob-in-hole, CrossMab, common light chain, or similar
- Chain pairing control and mispairing mitigation
- Binding kinetics (BLI or SPR)
- Basic biophysical profiling (DSF, DLS)
- Strong mechanistic understanding of antibody biology, structure, and expression bottlenecks
- A track record of successful and creative method development
- Travel 10% of time to Portland, OR
This listing is sourced directly from Twist Bioscience's careers page and normalized into a canonical job model.