Nurix Therapeutics

Nurix Therapeutics

Vice President, Translational Medicine & Clinical Biomarkers

Brisbane, California · Exec

Sponsorship not specified$332k-$378kDetected 3 days ago
Machine LearningData ScienceStatisticsBusiness DevelopmentPharmacologyPatient CareFDA RegulatoryFlow CytometryNGSResearchExperimental DesignProtein AnalysisAnimal StudiesAnimal ModelsLeadershipCollaborationPublic SpeakingBiostatisticsRegulatory Affairs

About the role

  • Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease.
  • Nurix Therapeutics is seeking an accomplished scientific leader to serve as Vice President, Translational Medicine & Clinical Biomarkers.
  • This is a senior executive role for a builder.

Responsibilities

  • Define and own the enterprise-wide translational medicine and clinical biomarker strategy across Nurix's pipeline, integrating insights from discovery through Phase II/III to inform portfolio prioritization and investment decisions.
  • Design and implement predictive biomarker strategies and translational plans to support indication selection and patient enrichment for degrader therapies.
  • Direct design and execution of pharmacodynamic, predictive, prognostic, and safety biomarker strategies for each program
  • Partner with Discovery Biology to build translationally anchored preclinical models and IND-enabling data packages that de-risk clinical hypotheses.
  • Direct design and execution of pharmacodynamic, predictive, prognostic, and safety biomarker strategies for each program; establish clear criteria for biomarker-driven decision gates.
  • Lead clinical biomarker data interpretation and synthesis across programs; translate complex datasets into actionable insights for clinical teams, executives, and regulatory agencies.
  • Provide scientific leadership for translational and biomarker content in clinical protocols, Investigator Brochures, clinical study reports, and regulatory submissions (INDs, BLAs, briefing documents).
  • Partner with Clinical Pharmacology on integrated PK/PD modeling, dose-response biomarker analysis, and mechanism-based endpoint selection.
  • Collaborate with Biostatistics and Data Science on statistical analysis plans, integrated translational datasets, and exploratory analyses that support publication and regulatory strategy.
  • Provide leadership in companion diagnostic (CDx) strategy, including CRO/IVD partner selection and regulatory co-development planning where applicable.

Requirements

  • Ph.D. in Immunology, Oncology, Biochemistry, Cell Biology, or a closely related life sciences discipline required
  • Postdoctoral training or equivalent advanced research experience in translational or clinical science is highly valued.
  • 15+ years of progressive experience in translational medicine and/or clinical biomarker research within the pharmaceutical or biopharmaceutical industry, with meaningful tenure in oncology.
  • Minimum 10 years in a senior leadership role (Sr.
  • Proven ability to evaluate, select, and govern external CRO, central laboratory, and academic partnerships in a biomarker development context.
  • Scientific & Technical Expertise
  • Deep expertise in translational biomarker strategy - target engagement, pharmacodynamic, predictive, prognostic, and safety biomarkers - with command of regulatory standards governing their use in clinical
  • Hands-on expertise or strong working knowledge of quantitative and multiplex biomarker technologies: flow cytometry, ELISA/MSD, IHC/mIF, NGS (RNAseq, scRNAseq, whole-exome), ctDNA/cfDNA, and digital
  • Familiarity with bioinformatic and computational approaches supporting multi-omic data integration and translational dataset interpretation

Nice to have

  • Direct experience with targeted protein degradation (PROTACs, molecular glues) or other emerging modalities, including translational challenges specific to novel mechanisms of action.
  • Publication record as senior or corresponding author
  • participation in scientific advisory boards or external translational medicine working groups.
  • Sees the intersection of targeted protein degradation and precision medicine as one of the most compelling opportunities in oncology, and is committed to defining what translational excellence looks like in this space.
  • Operates without ego at the executive table - direct, collaborative, and secure enough to be changed by data and by the perspectives of colleagues.
  • Has built things: functions, teams, capabilities.
  • MD/Ph.D. strongly preferred.

Skills

  • flow cytometry, ELISA/MSD, IHC/mIF, NGS (RNAseq, scRNAseq, whole-exome), ctDNA/cfDNA, and digital
  • Knowledge of regulatory expectations for exploratory biomarkers and IVD/CDx development strategies across FDA and EMA frameworks.
  • Experience in both oncology and immunology/inflammatory disease therapeutic areas, reflecting Nurix's evolving pipeline scope.
  • Fit with Nurix Culture and Values
  • Invests in people with the same intentionality as in the science - because at Nurix, those two things are inseparable.

Compensation

  • $332,140 - $377,560 range plus bonus and equity

Benefits

  • Equal Opportunity Employer offering a competitive salary and benefits package.

Equal opportunity

  • Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.
  • Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package.
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