Lgcgroup

Lgcgroup

Principal Chemist

Petaluma, CA, United States · Principal

Sponsorship not specifiedDetected 21 days ago
Data AnalysisStatisticsProject ManagementProcess ImprovementCustomer SupportBioinformaticsResearchExperimental DesignMass SpectrometryLeadershipCommunicationMentoringPublic Speaking

About the role

  • The Principal Oligonucleotide Chemist is a senior scientific leader responsible for driving oligonucleotide product development, synthesis, process development, and innovation across the Innovation Hub, operations, and customer‑facing programs.
  • This position plays a critical role in advancing LGC's oligonucleotide chemistry capabilities and new product offerings.

Responsibilities

  • Lead Petaluma Innovation Hub Oligo Chemistry Function by delivering customer co‑creation and NPD products/projects from concept through delivery.
  • Serve as a technical lead for multi-site, multi-function development team for oligonucleotide synthesis, modification, deprotection, purification, and analytical characterization.
  • Oversee and Execute oligo synthesis projects, including experimental design/planning, prioritization, and resource coordination.
  • Deliver and control new methods, workflows, and manufacturing protocols for oligonucleotide synthesis, purification and analysis. Support operations technically.
  • Optimize, and define manufacturing instructions for low‑yielding or impure processes.
  • Lead projects and staff hands-on in the lab by performing and training synthesis and purification of oligonucleotides using automated and manual techniques.
  • Develop and refine synthetic routes, synthesis method refinement, coupling conditions, deprotection strategies and purification methods.
  • Experimental Design, Data Analysis & Development Strategy

Requirements

  • Ph.D. in Synthetic Organic Chemistry, Chemical Biology, or related field inclusive of extensive experience in oligonucleotide chemistry.
  • Minimum of 15 years of direct industry experience in oligonucleotide synthesis, product and process development, and tech transfer into manufacturing.
  • Excellent communication skills, including the ability to present complex technical content to internal and external audiences.

Skills

  • With manufacturing sites across the US, UK, Germany and Denmark, LGC Biosearch Technologies has plans to continue growing.
  • Principal Oligonucleotide Chemist
  • Proven expertise in oligonucleotide chemistry.
  • Demonstrated knowledge of solid‑phase oligonucleotide synthesis and modification.
  • Skilled in analytical characterization of oligonucleotides, including impurity profiling.
  • Demonstrated project management skills with experience leading matrixed teams through complex development projects.
  • Participate in evaluation of new technologies and oligonucleotide market strategy
  • Conduct analytical characterization (LC‑MS, HPLC, CE, UV‑Vis) to confirm identity, purity, and impurity profiles.
  • Troubleshoot synthetic routes, instrument performance, and purification workflows and analytics to ensure consistent, high‑quality output.
  • Use mechanistic understanding and statistical analysis to adjust development plans and guide next‑step decision‑making.
  • Participate in technical customer calls related to custom oligo manufacturing, product investigations, and development updates.

Compensation

  • Minimum: $ 131,155/ Annualy
  • $196,733/ Anually
  • This range represents the low and high end of the anticipated salary range for the California -based position.
  • The actual base salary will depend on several factors such as:
  • experience, skills, and location.

Company info

  • LGC Biosearch Technologies
  • Type: Full‑time
  • Company Overview
  • LGC Biosearch Technologies operates across manufacturing sites in the US, UK, Germany, and Denmark, providing mission‑critical genomics solutions to customers in molecular diagnostics, pharma/biotech, and agrigenomics.
  • Our integrated portfolio of products, services, and expertise supports our mission of Science for a Safer World.
  • We partner closely with customers to enable research and development of life‑altering treatments for diseases worldwide.
  • Join our high‑growth, purpose‑driven organization.
  • Position Summary
  • This role blends hands‑on laboratory execution with strategic experimental design, data‑driven development, project leadership, and mentorship of scientists to deliver new products.
  • You will serve as the technical lead for Oligonucleotide New Product Development (NPD), and Customer co‑creation product projects, designing new manufacturing methods, troubleshooting complex issues, supporting tech transfer, and presenting technical content to commercial teams and customers.
  • Leadership in Oligonucleotide Chemistry, Project Execution and Delivery
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