Twist Bioscience
Sr Staff Program Manager, MES Custom Software Development Transformation
USA - South San Francisco, CA · Staff+
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DOL prevailing wage, 2026-27 wage year · Software Developers (15-1252) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
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About the role
- Partnering closely with Technology, Manufacturing Operations, R&D, Quality, and business stakeholders, this individual will be responsible for aligning priorities, managing complex dependencies, and driving decisions.
- Assist with organizational change management to ensure smooth system adoption and transition from legacy platforms. - Risk & Quality Management: Proactively identify technical, operational, and integration risks.
- About Twist Bioscience Twist Bioscience synthesizes genes from scratch, known as "writing" DNA.
Responsibilities
- Strategic Program Leadership: Lead the overall MES replatform transformation, translating strategic objective into an actionable, integrated program roadmap.
- MES Project Execution: Lead day-to-day execution of the MES replatform, managing timelines, scope, resources, and deliverable milestones.
- Stakeholder Engagement: Partner closely with business users, IT process owners, and external software vendors/agencies to communicate status, align expectations, and resolve cross-functional issues.
- Budget & Resource Management: Track project expenditures, support financial budgeting, and ensure efficient resource allocation across core initiative tracks.
- Process & Change Optimization: Implement company and departmental procedures that affect immediate operations. Assist with organizational change management to ensure smooth system adoption and transition from legacy platforms.
Requirements
- Overall experience: Minimum of 12 years of experience performing and improving business processes, with a strong focus on manufacturing, life sciences, engineering, or operations.
- Strong leadership, negotiation, and conflict-resolution skills, with a track record of translating complex manufacturing requirements into actionable software solutions.
- Education: Bachelor's degree in Computer Science, Software Engineering, Industrial Engineering, Information Technology, or a related field.
- Agile & Delivery Expertise: Proven expertise in Agile project delivery frameworks (Scrum Master, SAFe, or PMI-ACP certifications preferred) with a strong track record of facilitating Agile ceremonies and managing iteration cycles.
- Project Leadership: 5 plus years in project or program management leading cross-functional custom software development teams.
- Solid hands-on understanding of the custom software development lifecycle (SDLC), modern software architecture principles, and business transformation frameworks. Biotech or pharmaceutical industry experience is preferred.
Nice to have
- Certifications: Certified ScrumMaster (CSM), PMI-ACP, or SAFe Agilist.
- Industry Focus: Specialized experience in biotech, pharmaceutical, semiconductor, or advanced discrete manufacturing environments.
- Domain Knowledge: Deep understanding of custom software development lifecycles (SDLC), shop-floor manufacturing processes, SCADA/PLC integration, and ISA-95 standards.
- About Twist Bioscience
- Twist Bioscience synthesizes genes from scratch, known as "writing" DNA.
- Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.
- Twist Bioscience Corporation is an Equal Opportunity Employer.
- The base cash compensation for this California-based role is below.
Compensation
- San Francisco Bay Area Pay Range
Company info
- At Twist Bioscience, we work in service of people who are changing the world for the better.
- In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.
This listing is sourced directly from Twist Bioscience's careers page and normalized into a canonical job model.