10x Genomics

10x Genomics

Senior Research Associate- Diagnostic Assay Development

Pleasanton, California, USA HQ · Senior · Full-time

Sponsorship not specified$98k-$132kDetected 26 days ago
ForecastingExcelInventory ManagementClinical TrialsClinical ResearchBioinformaticsPCRqPCRMicroscopyMolecular BiologyNGSMedical DevicesResearchCommunicationCollaboration

About the role

  • 10x Genomics is establishing a diagnostics effort, translating our leading single cell and spatial assay technologies into impactful clinical applications.
  • We are seeking a highly skilled and motivated Senior Research Associate to join the Diagnostic Assay Development team.
  • The SRA will be a key contributor, executing the technical development, optimization, and rigorous testing of novel Laboratory Developed Tests (LDTs) in a dynamic, high-growth environment.

Responsibilities

  • Systematically troubleshoot, optimize, and refine specific steps within the assay workflow to improve performance, robustness, and efficiency.
  • Perform feasibility studies on new reagents, instrumentation, and process improvements for clinical readiness.
  • Prepare and process samples in support of large-scale clinical research studies
  • Generate and maintain meticulous laboratory records, protocols (SOPs), and batch records following Good Documentation Practices (GDP).
  • Support the transfer of robust assay workflows to the CLIA operations team.
  • Collaborate closely with R&D Scientists, Automation Engineers, and Bioinformatics teams to meet project milestones.
  • Work closely with the internal lab operations team to support the maintenance of a high-quality, organized laboratory environment, including inventory management and forecasting, equipment calibration, and ensuring compliance with safety standards.
  • Manager, Diagnostic Assay Development, requires extensive hands-on experience in advanced molecular biology techniques and a dedication to high-quality data generation in support of ambitious product development goals.

Requirements

  • B.S. with 5+ years or M.S. with 3+ years of hands-on experience in molecular diagnostics or genomics assay development in an industry setting.
  • Direct, demonstrable experience with advanced molecular technologies, particularly Next-Generation Sequencing (NGS) workflows
  • Exceptional proficiency in molecular biology techniques, including nucleic acid extraction, PCR/qPCR, and NGS library preparation
  • A proven track-record of using and optimizing and troubleshooting molecular biology protocols.
  • Experience working with challenging clinical sample types (e.g., FFPE tissue, primary tumor cells, low-input samples).
  • Prior hands-on experience with 10x Genomics single-cell or spatial technologies (e.g., Chromium or Xenium platforms) is a strong advantage.
  • Ability to organize, analyze, and interpret complex data sets (e.g., assay metrics, quality control data) and effectively troubleshoot issues based on results.

Nice to have

  • Experience working within a quality system or environment governed by CLIA, CAP, or ISO 13485 standards strongly preferred.
  • Experience with automated liquid handling for high-throughput assay execution is a strong advantage
  • experience with microscopy techniques a plus
  • Preferred Skills & Experience:

Skills

  • Commitment to rigorous execution, meticulous record-keeping, and high standards of scientific quality.
  • Thrive in fast-paced environments, and excel at managing multiple priorities, adapting to change, and consistently delivering results.

Compensation

  • $97,700 - $132,100 USD
  • About 10x Genomics
  • At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.
  • We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.
  • Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment.
  • We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides.
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