integratedbiosciencesinc

Senior Scientist, Drug Discovery Biochemistry & Biophysics

Redwood City, CA · Senior

H1B sponsorship availableDetected 23 days ago

ExpressRESTComputer VisionLogisticsPharmacologyqPCRMass SpectrometryProtein Analysis

About the role

Your work will generate decision-quality data on potency, selectivity, mechanism, kinetics, reversibility, compound artifacts, and molecular and cellular biology.
This role is ideal for someone who enjoys working at the interface of protein science, biophysics, cell-based pharmacology, and small molecule drug discovery.
If you're someone who loves making difficult assays work, understanding how compounds engage their targets to influence biology, and using rigorous quantitative data to guide drug discovery decisions, we want to hear from you.

We're seeking a driven and highly skilled Senior Scientist to build and execute our protein biochemistry, biophysics, and drug discovery assay capabilities.
Design, express, purify, and characterize recombinant proteins to support biochemical, biophysical, target engagement, and structural studies.
Develop, validate, and run biochemical and biophysical assays (FR, TR-FRET, AlphaScreen/AlphaLISA, DSF, enzymatic, SPR, BLI) to support hit validation, SAR, selectivity, mechanism of action, and lead optimization.
Generate quantitative data on affinity, potency, kinetics, residence time, reversibility, competition, allostery, selectivity, and design orthogonal assays.
Partner with medicinal chemistry to interpret SAR, prioritize compounds, and shape assay strategy.
Build focused cell-based assays that connect biochemical /biophysical target engagement to cellular pharmacology, covering target engagement, pathway modulation, biomarker response, potency, selectivity and counterscreens.
Develop fit-for-purpose readouts (e.g. high content cell imaging, qPCR, reporter, viability) for SAR and mechanism.

You're a good fit if you have
Experience with structural biology methods such as NMR, X-ray crystallography, or cryo-EM.
Familiarity with aging biology, senescence, mitochondrial function, proteostasis, inflammatory signaling, metabolic pathways, or other age-related disease biology.

We offer a highly competitive salary, substantial equity, and comprehensive benefits, including medical and dental coverage, company-provided lunch, 401k match, and others.

Senior Scientist, Drug Discovery Biochemistry & Biophysics
About Integrated Biosciences
At Integrated, we are focused on advancing small molecule therapeutics for age-related diseases.
We have built a first-of-its-kind discovery platform at the intersection of phenotypic models of aging, chemistry, and AI.
Backed by top-tier VCs, and with recent publications in Cell (2025), Nature (2024), Nature Aging (2023), and Nature Protocols (2025), we're rapidly expanding our senior scientific team to accelerate our growing pipeline.
We are an equal-opportunity employer and strongly encourage applications from individuals of diverse backgrounds, experiences, and perspectives.

This listing is sourced directly from integratedbiosciencesinc's careers page and normalized into a canonical job model.