Parabilis Medicines

Principal Scientist, Cell Pharmacology

Cambridge · Principal

Sponsorship not specified$160k-$190kDetected 34 days ago

Node.jsData SciencePharmacologyqPCRCRISPRFlow CytometryMolecular BiologyCell CultureResearchWestern BlottingLeadershipCommunicationMentoring

About the role

The company has pioneered a new class of alpha-helical peptides - Helicons™ - capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines.
Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications.
Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact.

B.S., M.S., PhD in cancer biology, molecular biology, or related discipline, with 15+ years of industry experience in drug discovery and cellular biology.
Experience in a biotech or pharma environment with increasing levels of responsibility is required.
Deep expertise in mammalian cell culture, CRISPR/RNAi-mediated gene modulation, western blotting, qPCR, flow cytometry, immunofluorescence, and high-content imaging platforms.
Strong working knowledge of data management platforms such as Dotmatics
Excellent communication and leadership skills, with the ability to influence across scientific disciplines and functional levels.
Demonstrated ability to work independently and collaboratively, prioritize effectively, and thrive in a dynamic, science-driven environment.

Serve as a subject matter expert on target engagement and functional assays, providing strategic guidance to cross-functional discovery teams.
Contribute to the strategic planning of IND-enabling studies and facilitate smooth transitions from discovery into development phases.
Serve as a mentor and technical advisor to junior scientists, fostering scientific rigor and growth within the biology organization.
Champion scientific innovation, propose novel assay formats and platforms, and evaluate emerging technologies for internal application.
Actively contribute to a dynamic and collaborative scientific culture dedicated to transforming oncology therapy through groundbreaking science.
Demonstrated ability to utilize AI tools for day-to-day work
baseline proficiency is expected, and advanced or innovative use of AI is a strong plus.
Recognized internally and externally for scientific contributions, with authorship on peerreviewed publications or patents strongly preferred.

The base salary range for this position is $160,000-$190,000, depending on experience, qualifications, and internal practices.

This listing is sourced directly from Parabilis Medicines's careers page and normalized into a canonical job model.