Arrowhead Pharmaceuticals

Senior Scientist I, DMPK

Madison, Wisconsin, United States · Senior

Sponsorship not specified$115k-$140kDetected 19 days ago

GCPPharmacologyResearchExperimental DesignMass SpectrometryAnimal StudiesLeadershipCommunicationProblem Solving

About the role

Arrowhead Pharmaceuticals is seeking an accomplished Senior Scientist, DMPK to play a key role in advancing our growing pipeline of RNAi-based therapeutics.
The ideal candidate brings deep technical expertise, strong problem-solving skills, and the ability to thrive in a fast-paced, collaborative environment dedicated to scientific excellence and innovative drug development.

Develop and implement in vitro and in vivo DMPK strategies to support preclinical development for compounds across multiple indications and routes of administration.
Manage all DMPK activities, including oversight of internal resources and CRO partners to ensure high-quality and timely data delivery.
Design, supervise, and execute preclinical PK studies, including non-compartmental analysis (NCA), data interpretation, reporting, and communication of PK/PD insights to project teams.
Prepare and deliver IND-enabling DMPK packages, ensuring compliance with regulatory expectations and contributing to regulatory submissions.
Support GLP toxicokinetic (TK) study design, analysis, and reporting.
Contribute to a dynamic, fast-paced DMPK team by offering scientific leadership, troubleshooting support, and cross-functional collaboration.
Maintain a current understanding of clinical pharmacology literature and regulatory guidance for oligonucleotide/RNAi therapeutics.

PhD in Pharmacometrics, Drug Metabolism, Pharmaceutical Sciences, or a related discipline with at least 3 years of industry experience.
Deep and broad expertise in DMPK, with working knowledge of nucleotide or oligonucleotide drug metabolism and distribution highly desired.
Hands-on experience with in vitro ADME assays, in vivo PK studies, drug-drug interaction (DDI) evaluations, and Phoenix WinNonlin.
Experience with LC-MS/MS and HRMS, ideally applied to oligonucleotide therapeutics.
Demonstrated experience in drug development and understanding of regulatory processes.
Excellent interpersonal, verbal, and written communication skills, with the ability to interpret and present complex scientific data clearly.
Candidates must have current, valid authorization to work in the country where this role is located.

This listing is sourced directly from Arrowhead Pharmaceuticals's careers page and normalized into a canonical job model.