Novartis

Novartis

Principal Scientist, Structural Biology

San Diego · Principal

Sponsorship not specifiedDetected 12 days ago
Machine LearningData AnalysisInventory ManagementClinical TrialsCRISPRResearchProtein AnalysisCommunicationCollaborationProblem Solving

About the role

  • At Novartis, we are reimagining medicine through scientific excellence and innovation.
  • Within the Discovery Sciences organization, the Protein Sciences group plays a pivotal role in advancing early-stage drug discovery by enabling deep structural and functional insights into therapeutic targets.
  • Structural Biology is a cornerstone capability, enabling structure-guided drug discovery for some of the most challenging and high-impact targets in medicine.

Responsibilities

  • Lead and execute protein production and X-ray crystallography to elucidate protein-small molecule, protein-peptide, and/or protein-protein interactions, supporting drug discovery initiatives
  • Successfully drive gene-to-structural small molecule drug discovery projects
  • Collaborate with cross-functional teams, including protein scientists, biophysicists, chemists, and computational modelers, to facilitate structure-based drug design
  • Outstanding communication skills, strong ability to collaborate within multidisciplinary teams, and ability to work in a fast-paced, goal-driven environment.

Requirements

  • Ph.D. in structural biology, biophysics, biochemistry, or a related field with over 5 years of relevant experience in X-ray crystallography within either industrial or academic settings
  • Demonstrated expertise in protein expression across E. coli, insect, and mammalian expression systems, as well as extensive experience in protein purification and characterization
  • Experience with biochemical assays and biophysical methods

Nice to have

  • Experience with Cryo-EM is a plus

Compensation

  • $108,500.00 - $201,500.00
  • The salary for this position is expected to range between $108,500 and $201,500 per year for Principal Scientist I, and between $119,700 and $222,300 per year for Principal Scientist II.
  • The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically.
  • Novartis may change the published salary range based on company and market factors.
  • Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

Benefits

  • US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits.
  • In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.
  • To learn more about the culture, rewards and benefits we offer our people click here.

Company info

  • We are seeking a Principal Scientist with deep expertise in Structural Biology to join our team in San Diego, CA.

Equal opportunity

  • The Novartis Group of Companies are Equal Opportunity Employers.
  • Accessibility and reasonable accommodations
  • The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities.
  • Please include the job requisition number in your message.
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This listing is sourced directly from Novartis's careers page and normalized into a canonical job model.