Epicrispr Biotechnologies

Epicrispr Biotechnologies

Research Associate II/ Senior Research Associate, In Vitro Pharmacology

South San Francisco, California, United States · Senior

Sponsorship not specifiedDetected 42 days ago
Data AnalysisA/B TestingPharmacologyPCRqPCRCRISPRFlow CytometryMicroscopyMolecular BiologyCell CultureResearchExperimental DesignProtein AnalysisWestern BlottingAnimal StudiesProblem SolvingPublic Speaking

About the role

  • The ideal candidate brings hands-on expertise in molecular and cellular biology, gene editing technologies, and disease-relevant cellular models.
  • Experience in neuromuscular disease biology, gene therapy, or epigenetic regulation is highly desirable.

Responsibilities

  • Design, execute, analyze, and interpret in vitro pharmacology experiments that support therapeutic candidate discovery and advancement.
  • Develop and optimize cellular assays to evaluate CRISPR-based epigenetic editing systems, including potency, durability, specificity, and mechanism of action, to inform program decisions.
  • Generate high-quality datasets and apply rigorous analysis to support data-driven program decisions.
  • Partner closely with cross-functional teams to advance therapeutic programs.
  • Perform molecular and cellular analyses including qPCR, RT-qPCR, digital PCR, Western blotting, ELISA, flow cytometry, immunofluorescence, and next-generation sequencing-based assays.
  • Maintain detailed experimental records and contribute to study reports, presentations, and regulatory documentation.
  • In this role, you will design and execute in vitro studies to characterize the activity, potency, mechanism of action (MoA), and translational potential of CRISPR-based gene regulation therapeutics.

Requirements

  • 3-5+ years of relevant industry experience.
  • B.S. or M.S. with 5-8+ years of industry experience.
  • Demonstrated ability to independently execute complex studies and contribute to experimental strategy.

Nice to have

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Skills

  • Hands-on experience with CRISPR technologies, including CRISPR-Cas9, CRISPRi, CRISPRa, or epigenome editing (Preferred) platforms.
  • Strong molecular biology skills including nucleic acid extraction, PCR, qPCR, dPCR, cloning, and gene expression analysis.
  • Mammalian cell culture and cellular assay development experience.
  • Experience with viral vector systems (AAV, lentivirus, or related gene therapy platforms).
  • Proficiency in flow cytometry, immunofluorescence staining, microscopy, and protein expression analyses.
  • Strong data analysis, experimental design, and troubleshooting skills.

Company info

  • Our company is based on the science of our founder, Stanley Qi, one of the original CRISPR co-inventors who then furthered the technology so that DNA does not need to be cut to accomplish gene regulation.
  • Instead, we regulate the epigenome to suppress and activate multiple genes simultaneously.
  • We are further evolving the platform and leveraging its strengths to address unmet medical needs.
  • We are looking for exceptional team members who want an active role in building a rapidly growing biotech.
  • We are seeking an exceptional Research Associate II or Senior Research Associate to join our In Vitro Pharmacology team.
  • In this role, you will help advance CRISPR-based epigenetic therapies from discovery through preclinical development, with a focus on neuromuscular and rare genetic diseases.
  • This position is ideal for a highly motivated scientist who enjoys hands-on experimentation, critical data analysis, and scientific problem-solving in a fast-paced biotechnology environment, with the opportunity to take increasing ownership of projects and grow into more independent scientific roles.
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