Generate Biomedicines

Scientist I / Scientist II, Computational Protein Generation

Somerville, MA · Mid

Sponsorship not specified$154k-$216kDetected 98 days ago

PythonMachine LearningAgentic AIA/B TestingRecruitingBioinformaticsResearchAnimal StudiesLeadership

About the role

You will join a talented and collaborative group of ML scientists, engineers, and wet-lab scientists dedicated to redefining how medicines are made.
You don't just run existing tools; you understand what's missing from current approaches and are driven to fill those gaps.
This role is based in our Somerville, MA office with flexibility for hybrid work.

develop, validate, and productionize de novo protein generation protocols and optimization techniques on our experimental platform, using measured data in-the-loop to iteratively refine models across modalities and therapeutic applications.
design, interpret, and implement biophysical and functional metrics for evaluating generated designs, leveraging existing literature, adapting known metrics to new contexts, and performing original research to benchmark and deploy new scoring approaches.
work closely with experimental colleagues, biologists, and clinical scientists to define design objectives, interpret experimental readouts, and guide iterative design-build-test-learn cycles that advance programs.
PhD in Computational Biology, Biophysics, Computer Science, or a related field, with demonstrated experience in protein design applications.
Experience designing, executing, and interpreting experiments and experimental data (e.g., binding assays, stability measurements, structural characterization) and using those readouts to inform computational design iterations.

0-2 years of experience applying computational and/or ML methods to protein design, modeling, or prediction.
Proficiency in Python and scientific computing
comfort working in a production codebase.
Experience designing, running, or interpreting benchmarks for computational or generative methods and drawing quantitative conclusions about model applicability and limitations.
Familiarity with agentic AI tools and their integration into scientific workflows.
Track record of translating research ideas into working software or reusable platform components used across multiple projects or applications.

The base salary range provided reflects our current estimate of what we anticipate paying for this position.
Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics.
In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.
Per Year Salary Range
$154,000 - $216,000 USD

Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates.
The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company's internal Talent Acquisition team.
Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.
We are seeking a creative, motivated Computational Scientist to join our Model-Driven Design team at Generate:Biomedicines.

al employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status

This listing is sourced directly from Generate Biomedicines's careers page and normalized into a canonical job model.