Twenty Twenty Therapeutics

Twenty Twenty Therapeutics

Product Manager

Arlington, VA · Exec · Full-time

Work authorization requiredDetected 128 days ago
Leadership

About the role

  • ABOUT THE COMPANY America is under sustained cyber attack.
  • Our adversaries infiltrate our networks, steal our IP, and degrade the digital infrastructure that modern life runs on.
  • They've learned-correctly-that those attacks rarely produce consequences.

Responsibilities

  • Partner closely with operational stakeholders to understand workflows, constraints, and what success looks like in practice.
  • Drive product decisions using a mix of user feedback, qualitative insight, and technical understanding.
  • Support products deployed in constrained or non-standard environments, including bespoke or air-gapped infrastructure.
  • Create alignment across engineering, operators, and leadership on what to build, why it matters, and what comes next.

Requirements

  • You are energized by hard, ambiguous problems where there is no obvious playbook.
  • You have strong judgment and handle sensitive work with discretion and maturity.
  • You are comfortable working closely with technical teams and expert users, even when requirements are incomplete or evolving.
  • You communicate clearly and directly, whether you are aligning engineers, operators, or leadership.
  • You are curious about offensive cyber and adjacent mission domains, even if you have not worked in them before.
  • You are at your best in small, high-trust teams with high standards and real ownership.
  • You are comfortable in high-speed, high-stakes environments, and take the initiative to solve problems even when they fall outside your direct job role.
  • You have 4+ years of experience building products.
  • You have experience as a Product Manager or in a closely related role, such as technical program manager, founder, or engineer with meaningful product ownership.
  • You have strong technical fluency and can engage meaningfully with engineers on architecture, tradeoffs, feasibility, and delivery risk.

Nice to have

  • You have experience with offensive cyber operations, cyber intelligence, red teaming, or adjacent domains.
  • You have built or managed AI-driven or agentic products.
  • You have a background in data platforms, analytics, knowledge graphs, or complex backend systems.
  • You have worked in government, defense, intelligence, or similarly mission-driven environments.
  • You might work with products deployed in air-gapped or bespoke infrastructure environments.
  • You might work with data platforms, analytics systems, or knowledge graph-oriented capabilities.
  • You might work in environments where reliability, security, and operational usability matter as much as feature velocity.
  • You must be a U.S. citizen and eligible to obtain a U.S. Government security clearance.

Benefits

  • Medical, dental, and vision plan options.
  • Life / AD&D, disability coverage options.
  • Paid parental leave for eligible full-time employees.
  • Paid holidays and flexible PTO.
  • HSA/FSA options, dependent care FSA.
  • Commuter benefits.
  • Building fitness center.
  • Desk setup stipend.
  • We consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, veteran status, disability, or any other protected status.
  • Own product vision, strategy, and execution for one or more mission-critical capabilities.
  • Benefits vary by location, role, and eligibility.

Company info

  • America is under sustained cyber attack.
  • Twenty was founded to change that, by making our adversaries think twice before they attack us.
  • Our vision is American and allied primacy in cyberspace-a future where they cannot contest us, deterrence is assured, and the free world remains secure.
  • Founded in 2024, Twenty Technologies (www.twenty.io http://www.twenty.io) industrializes offensive cyber operations for the U.S. and its allies.
  • Headquartered in Arlington, Virginia, Twenty has raised $138M from Accel, Caffeinated Capital, Friends & Family Capital, Point72 Ventures, General Catalyst, and In-Q-Tel.
  • You will own and drive products that directly support offensive cyber missions, turning real operational needs into scalable, high-impact software.
  • This is a product role for someone who is comfortable in ambiguity, can make hard decisions, and knows how to prioritize outcomes over process.
  • You will work closely with engineers, operators, and leadership to shape mission-critical capabilities used by experts under pressure.
  • The problems are complex, the environments non-standard, and the products you build will be used in real operations where reliability and clarity matter.

Equal opportunity

  • equal opportunity employer.
  • If you need a reasonable accommodation during the hiring process, let us know and we will work with you.

Visa & Work Authorization

  • citizen and eligible to obtain a U
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This listing is sourced directly from Twenty Twenty Therapeutics's careers page and normalized into a canonical job model.