Vir Biotechnology

Vir Biotechnology

Senior Director, Clinical Operations Oncology

San Francisco, California, United States · Director · Full-time

No sponsorship$236k-$329kDetected 1 day ago
GCPForecastingProcess ImprovementHRIntellectual PropertyClinical TrialsPharmacologyFDA RegulatoryAnimal StudiesLeadershipCollaborationMentoringRegulatory Affairs

Stay score

odds of building a lasting career here

59Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role80
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.

Lottery odds assume a STEM candidate.

Personalize to your clock →

H-1B wage level

the lottery is wage-weighted — each level is one more entry

Level II · 2×
Level I$167,6481 entry
Level II$208,5822 entries
Level III$249,5383 entries
Level IV$290,4724 entries

$14,038 more — $249,538 — moves this role to Level III and 3 lottery entries. That figure is inside the range the employer already advertised.

Based on the DOL prevailing wage for this occupation and worksite, a base salary of $249,538 would place this position at wage Level III. That figure is within the posted range, and I'd like to target it. This role classifies under "Natural Sciences Managers" for prevailing-wage purposes.

DOL prevailing wage, 2026-27 wage year · Natural Sciences Managers (11-9121) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.

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About the role

  • Vir Biotechnology is seeking an experienced Senior Director of Clinical Operations to provide portfolio-level strategic and operational leadership for multiple complex global oncology programs.
  • The role will serve as a hands-on leader across study execution, program governance, alliance management, operational excellence, and oncology portfolio growth.
  • You will establish the operational strategy for assigned programs and provide effective sponsor oversight of CROs, clinical sites, laboratories, and specialty vendors.

Responsibilities

  • Provide strategic and operational leadership for first-in-human, dose-escalation, dose-optimization, backfill, combination, and expansion-cohort oncology studies, including rapid cohort activation, fit-for-purpose safety oversight, intensive pharmacokinetic and biomarker sampling, and timely delivery of data to support dose, indication, and portfolio decisions.
  • Implement and oversee risk-based quality management plans, sponsor-oversight activities, and inspection-readiness strategies across all assigned studies
  • Drive Clinical Operations excellence by serving as the Clinical Operations subject matter expert for assigned clinical studies and leading cross-functional initiatives, including KPI tracking, process improvement, and oversight to ensure adherence to protocols, project plans, and GCP requirements
  • Partner with senior leadership to foster a highly desirable work environment that attracts and retains high-performing Clinical Operations professionals
  • Build, lead, and develop a high-performing Clinical Operations team through effective management, coaching, and professional development of direct reports
  • Mentor junior Clinical Operations colleagues and contribute to building organizational capabilities that support a growing oncology portfolio
  • Develop company SOPs, guidelines, and efficient systems in collaboration with the Clinical Operations team to enhance departmental effectiveness and ensure compliance with applicable FDA regulations and current ICH GCP guidelines
  • Serve as the operational lead for alliance and co-development programs, representing Clinical Operations in joint governance forums and facilitating cross-company operational alignment
  • Lead Clinical Operations planning for emerging oncology assets transitioning from preclinical development into the clinic, including first-in-human operational strategy, country and site assessment, vendor and systems readiness, initial budget and resource assumptions, and execution planning aligned with regulatory submission and study-start milestones.
  • Proven ability to influence cross-functional program strategy and drive timely decisions in a fast-paced biotechnology environment

Requirements

  • Bachelor's degree in life sciences or a related field and 15+ years of clinical development experience in the biotechnology or pharmaceutical industry
  • Significant experience overseeing complex global oncology clinical trials, with deep expertise in early-phase oncology development
  • Demonstrated experience leading first-in-human and early-development oncology trials, including dose-escalation, backfill, expansion, signal-seeking, and dose-optimization studies
  • Experience supporting development of novel oncology modalities, such as T-cell engagers, bispecific antibodies, immuno-oncology therapies, cell therapies, cytokine-based therapies, or related platforms
  • Strong understanding of clinical trial design and execution, including operational considerations in oncology studies
  • Extensive knowledge of FDA, EMA, ICH GCP, and other global regulatory requirements.
  • Experience managing CROs and vendors across global clinical development programs
  • Experience supporting regulatory inspections, audits, and inspection readiness activities
  • Experience contributing to departmental initiatives, process improvements, and operational excellence programs
  • Ability to travel domestically and internationally as needed.

Skills

  • Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies.
  • Vir Biotechnology has exclusive rights to the universal PRO-XTEN ® masking platform for oncology and infectious disease.
  • PRO-XTEN ® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company.

Compensation

  • The expected salary range for this position is $235,500 to $329,000 per year.

Company info

  • The expected salary range for this position is $235,500 to $329,000 per year.
  • Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors.
  • Vir Biotechnology's compensation and benefits are aligned with the current market and commensurate with the person's experience and qualifications.
  • All full-time employees receive a package that includes compensation, bonus and equity as well as many other Vir Biotechnology benefits and perks such as health and welfare benefit plans, non-accrual paid time off, company shut down for holidays, commuter benefits, 401K match and lunch each day in the office.
  • Applicants must currently be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.
  • All employment decisions at Vir Biotechnology are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications.
  • Employment decisions are made without regard to any legally protected characteristics.
  • This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs.
  • Vir Biotechnology also strongly commits to providing employees with a work environment free of unlawful conduct or harassment.
  • Vir Biotechnology Human Resources leads recruitment and employment for Vir Biotechnology.
  • Unsolicited resumes sent to the company from recruiters do not constitute any type of relationship between the recruiter and Vir Biotechnology and do not obligate us to pay fees should we hire from those resumes.
  • We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.
  • For hires based in the United States, Vir Biotechnology, participates in E-Verify.

Visa & Work Authorization

  • You will establish the operational strategy for assigned programs and provide effective sponsor oversight of CROs, clinical sites, laboratories, and specialty vendors.
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This listing is sourced directly from Vir Biotechnology's careers page and normalized into a canonical job model.