Nudge (nudge.com)
Histotechnologist
San Francisco
Sponsorship not specifiedDetected 124 days ago
MicroscopyResearch
About the role
- As a histotechnologist at Nudge, you will:
- Execute standard histological stains (H&E, special stains) and immunohistochemistry using both manual and automated staining platforms
- Prepare cleared tissue for light sheet fluorescence microscopy and volumetric 3D imaging
Responsibilities
- We're starting with an approach that we believe can help the most people the fastest, and also allow us to learn as much about the brain as possible: developing a non-invasive, ultrasound-based device that can stimulate and image the brain at high resolution and depth.
- Perform routine and advanced histological processing of rodent brain tissue, including perfusion, prosection, fixation, embedding (paraffin and OCT), and sectioning via microtome, cryostat, and vibratome
- Operate and optimize tissue clearing platforms (electrophoretic, solvent-based) for whole-brain and thick-section imaging
- Operate and maintain automated sectioning and tissue processing systems
- Develop, optimize, and document SOPs for histological workflows, ensuring reproducibility and quality
- Collaborate with research scientists to adapt tissue processing and staining strategies to specific experimental questions
Requirements
- Proficiency across core histological techniques: microtomy (paraffin, cryo, vibratome), tissue embedding, H&E staining, and immunohistochemistry
Nice to have
- Experience with at least one tissue clearing method and associated imaging modalities (light sheet microscopy)
- Familiarity with automated staining and sectioning platforms
- HT(ASCP) certification or equivalent training
- Bachelor's degree in biology, neuroscience, or a related field preferred
- High integrity and strong professional judgment
Benefits
- This is a vertically integrated effort building cutting-edge hardware, software, and research capabilities to create products that can benefit millions - and eventually billions - of people.
Company info
- We are looking for histotechnologists with at least 3 years of industry experience.
- At Nudge, our mission is to develop the best technology for interfacing with the brain to improve people's lives.
- We're looking for a Histotechnologist to own and execute histology workflows at Nudge, focused primarily on mouse and rat brain tissue.
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