Vir Biotechnology
Director, Clinical Operations
San Francisco, California, United States · Director · Full-time
No sponsorship$204k-$284kDetected 25 days ago
GCPProcess ImprovementHRIntellectual PropertyClinical TrialsPharmacologyFDA RegulatoryAnimal StudiesLeadershipProblem SolvingRegulatory Affairs
Stay score
odds of building a lasting career here
59Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role80
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70
Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
Level I$167,6481 entry
Level II$208,5822 entries
Level III$249,5383 entries
Level IV$290,4724 entries
$5,082 more — $208,582 — moves this role to Level II and 2 lottery entries. That figure is inside the range the employer already advertised.
Based on the DOL prevailing wage for this occupation and worksite, a base salary of $208,582 would place this position at wage Level II. That figure is within the posted range, and I'd like to target it. This role classifies under "Natural Sciences Managers" for prevailing-wage purposes.
DOL prevailing wage, 2026-27 wage year · Natural Sciences Managers (11-9121) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
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About the role
- Vir Bio is seeking an experienced Director, Clinical Operations to provide strategic and operational leadership for global oncology clinical trials.
- The individual will serve as a hands-on study leader responsible for the successful execution of complex clinical studies while contributing to broader program strategy, alliance management, operational excellence initiatives, and portfolio expansion efforts.
- You will serve as a key member of cross-functional program teams, providing operational leadership from protocol development through study closeout.
Responsibilities
- Serve as the Clinical Operations lead and study owner for one or more global oncology clinical trials, with accountability for successful delivery against timelines, budget, quality, and milestones
- Provide strategic and operational leadership for first-in-human, dose-escalation, dose-optimization, backfill, and expansion-cohort oncology studies, ensuring efficient execution and generation of high-quality data to support development decisions
- Develop and execute global site and enrollment strategies, including investigator engagement, site feasibility, country selection, academic-center activation, and enrollment-acceleration activities
- Lead Study Management Teams and drive cross-functional decision-making to ensure efficient study conduct
- Act as the primary point of accountability for CROs, central laboratories, technology vendors, and other external partners
- Develop and maintain study timelines, budgets, forecasts, and risk management plans, proactively identifying and mitigating issues
- Author, review, and provide operational input into protocols, informed consent forms, study plans, charters, and other key study documents
- Lead vendor selection activities, including RFP development, bid evaluation, contracting, and ongoing oversight
- Drive continuous improvement across Clinical Operations through SOP development, process optimization, training initiatives, and departmental projects
Requirements
- Bachelor's degree in Life Sciences or related field and 12+ years of clinical development experience within the biotechnology or pharmaceutical industry
- Significant experience leading complex global oncology clinical trials, with deep expertise in early-phase oncology development
- Demonstrated experience leading first-in-human and early-development oncology trials, including dose-escalation, backfill, expansion, signal-seeking, and dose-optimization studies.
- Experience supporting development of novel oncology modalities, such as T-cell engagers, bispecific antibodies, immuno-oncology therapies, cell therapies, cytokine-based therapies, or related platforms.
- Demonstrated expertise in global study start-up, site strategy, enrollment optimization, and recruitment planning across academic and community oncology networks
- Strong understanding of clinical trial design and execution, including operational considerations in oncology studies
- Extensive knowledge of FDA, EMA, ICH-GCP, and global regulatory requirements
- Experience managing CROs and vendors across global clinical development programs
- Experience supporting regulatory inspections, audits, and inspection readiness activities
- Demonstrated ability to balance strategic thinking with hands-on execution and operational problem-solving
Compensation
- The expected salary range for this position is $203,500 to $284,000 per year.
Benefits
- Provide operational leadership and input for regulatory submissions, health authority interactions, and inspection readiness activities
Company info
- The expected salary range for this position is $203,500 to $284,000 per year.
- Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors.
- Vir Biotechnology's compensation and benefits are aligned with the current market and commensurate with the person's experience and qualifications.
- All full-time employees receive a package that includes compensation, bonus and equity as well as many other Vir Biotechnology benefits and perks such as health and welfare benefit plans, non-accrual paid time off, company shut down for holidays, commuter benefits, 401K match and lunch each day in the office.
- Applicants must currently be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.
- All employment decisions at Vir Biotechnology are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications.
- Employment decisions are made without regard to any legally protected characteristics.
- This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs.
- Vir Biotechnology also strongly commits to providing employees with a work environment free of unlawful conduct or harassment.
- Vir Biotechnology Human Resources leads recruitment and employment for Vir Biotechnology.
- Unsolicited resumes sent to the company from recruiters do not constitute any type of relationship between the recruiter and Vir Biotechnology and do not obligate us to pay fees should we hire from those resumes.
- We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.
- For hires based in the United States, Vir Biotechnology, participates in E-Verify.
Visa & Work Authorization
- Applicants must currently be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.
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This listing is sourced directly from Vir Biotechnology's careers page and normalized into a canonical job model.