Legend Biotech US

Scientist, Solid Tumor CAR-T

Philadelphia, PA · Full-time

No sponsorship$111k-$145kDetected 17 hours ago

Data AnalysisIntellectual PropertyPCRqPCRFlow CytometryMolecular BiologyResearchAnimal StudiesCollaborationPublic Speaking

About the role

We are seeking a highly motivated Scientist to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors.
The ideal candidate holds a PhD in Immunology, Immuno-Oncology, or a closely related discipline, with up to 3 years of postdoctoral experience.
You are a rigorous scientist who thrives in a fast-paced, collaborative environment and is passionate about translating basic immunology insights into transformative oncology therapies.

Maintain detailed experimental records
Maintain detailed experimental records; contribute to scientific reports, presentations, and patent documentation.
panel design, data acquisition (e.g., Attune,Novocyte, Cytek Aurora), and analysis (FlowJo).

Primary human T cell isolation, activation, lentiviral transduction, and expansion is required.
Familiarity with Incucyte, MSD, LDH release assay.
Applicants must be authorized to work in the United States.
If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law.

Experience with PDX model development for CAR-T evaluation is preferred.
Knowledge in specific tumor disease area is preferred.
Experience with single cell sequencing and data analysis/interpretation is preferred.

Design and execute in vitro functional assays.
Perform Binder selection for CAR design.
Handling and engineering human and murine T cells.
Engineering and maintaining various cancer cell lines for model development.
Analyze and interpret data, troubleshooting, present to and engage internal stakeholders

Performance-based bonus and/or equity is available to employees in eligible roles.
Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one.
Please note: These benefits are offered exclusively to permanent full-time employees.
Contractors are not eligible for benefits through Legend Biotech.

This role is central to our in vivo CAR-T platform and will drive preclinical development from construct design through animal model efficacy studies.

This listing is sourced directly from Legend Biotech US's careers page and normalized into a canonical job model.