Madrigal Pharmaceuticals

Madrigal Pharmaceuticals

Senior Biostatistician

PA - Conshohocken - Office, USA · Senior · Full-time

Sponsorship not specified$147k-$179kDetected 27 days ago
StatisticsCompensationClinical TrialsClinical ResearchFDA RegulatorySASResearchCommunicationBiostatistics

About the role

  • Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.
  • Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3).
  • An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Responsibilities

  • Perform and review complex statistical analyses, contribute to protocol development and prepare Statistical Analysis Plans as needed.
  • Contribute to the design and analysis of clinical and real-world data to support evidence generation initiatives from randomized trials as well as observational studies.
  • Madrigal's medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH.
  • This role will collaborate with other biostatisticians, programmers and cross-functional team members either within the company or at a CRO partner to ensure that Madrigal's analytical objectives are met.
  • The incumbent will support the translation of organizational objectives into statistical deliverables, contribute to the execution of statistical strategies, and deliver high-quality analytical outputs.
  • This role provides hands-on biostatistics experience in clinical development and post-marketing evidence generation, while building expertise under senior statistical guidance.

Requirements

  • Ph.D. in (Bio)statistics with 2+ years, or a Master's degree with 5+ years of experience in a Pharma or Biotech environment.
  • Experience in design and analysis of clinical trials and healthcare datasets.
  • Solid foundation in advanced statistical methods and computing (R, SAS).
  • Effectively communicates complex statistical analyses and concepts to non-statisticians.
  • Excellent organizational and communication skills.
  • Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
  • All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate's qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $146,700 - $179,300 per year. We comply with all applicable minimum wage laws.
  • All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
  • Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.
  • We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com.
  • Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Nice to have

  • Knowledge of regulatory guidelines in pharmaceutical development is a plus.

Compensation

  • Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity.

Benefits

  • Establish effective collaborations with cross-functional team members, such as clinical research, medical affairs, clinical operations and data management.

Company info

  • Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality.
  • We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration.
  • To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.
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This listing is sourced directly from Madrigal Pharmaceuticals's careers page and normalized into a canonical job model.