Resilience

Resilience

Scientist II, Cell Line Development

CAN - ON - Mississauga - Meadowpine Blvd · Mid

Sponsorship not specified$90k-$131kDetected 57 days ago
FlaskData AnalysisAccessibilityExcelCustomer SupportGMPMolecular BiologyCell CultureResearchMass SpectrometryProtein AnalysisLeadershipCommunicationProblem SolvingMicrosoft Office

About the role

  • A career at Resilience is more than just a job - it's an opportunity to change the future.
  • Resilience is a technology-focused biomanufacturing company that's changing the way medicine is made.
  • The position requires good documentation practices and routine reporting and communication of results, both internally as well as to clients.

Responsibilities

  • Maintain strong technical expertise in the full scope of therapeutic protein cell line development covering vector construction (DNA plasmids), transfection (or other means) into host cell line, clone generation, screening and selection (imaging), cell line stability (genetic) and characterization (sequencing), and associated analytics (titer, growth characteristics, metabolites analysis, etc.)
  • Identify, offer, and implement contingency plans to prevent and overcome issues; perform method troubleshooting; identify issues, solve problems and incorporate changes into ongoing development experiments
  • Manage inventory control and tracking of material generated from processes
  • Recommend, acquire and maintain equipment suitable for current industry standard cell line development work
  • Routine maintenance of cell lines, RCBs; support maintenance of MCBs and WCBs; this includes the documentation review of client cell bank analytical and safety testing prior to receipt at RBI's facility
  • We're building a sustainable network of high-tech, end-to-end manufacturing solutions to better withstand disruptive events, serve scientific discovery, and reach those in need.
  • The Scientist II (Molecular and Cellular Biology) is a technical expert who will lead cell line development in support of manufacturing projects for biopharmaceutical products at RBI.
  • The current role requires leading the design, engineering, and optimization of mammalian cell lines for the production and manufacturing of recombinant biopharmaceutical therapeutic proteins (e.g., monoclonal antibodies, bispecific antibodies, fusion proteins).

Requirements

  • Deep knowledge of recombinant protein expression, molecular and cell biology, cell line development and characterization
  • Operational knowledge and hands-on experience with various cell line development instrumentation, e.g., Solentim VIPS, Cell Metric, Octet, CEDEX, BPFlex, Ambr250
  • Data analysis and report preparation with knowledge of MS Word, Excel, PowerPoint and Outlook
  • Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
  • Knowledge of aseptic techniques
  • [insert options from job description template] The items described here are representative of those that must be met successfully to perform the essential functions of this job.

Nice to have

  • Ph.D. or M.Sc. degree in Molecular Biology, Cell Biology, Biochemical Engineering
  • Minimum of 5 years (7 years if M.Sc.) of recent scientific and industrial experience in a biotechnology development and manufacturing environment
  • Knowledge and experience with routine biologics analytical testing: HPLC, CE-SDS, ELISA, plate-based assays
  • Expert at cell culture techniques with bench scale (bioreactors)
  • This position requires vaccination for Hepatitis A and B
  • Job requires occasional shift work, weekends and extended shifts, with possible schedule shift changes on short notice
  • Demonstrated ability to apply the following behavioural competencies on the job:
  • Problem Solving: Anticipating, analysing, diagnosing and resolving problems in a manufacturing environment

Compensation

  • Our target base pay hiring range for this position is $90,000.00 - $131,250.00 per year.

Benefits

  • In areas of health, safety and environmental policies, contribute toward meeting departmental/company goals

Company info

  • Utilizing effective processes to make decisions
  • The work schedule listed reflects the employee's expected schedule at the time of hire.
  • The Company reserves the right to modify work schedules at any time, with or without notice, based on business needs, operational requirements, or other considerations.
  • Nothing in this description creates a guarantee of specific hours, days, or shift assignments.

Equal opportunity

  • Requests for accommodation can be made at any stage of the recruitment process.
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