Neurocrine Biosciences
Scientist II, Lead Generation Biology
US CA San Diego · Mid
Sponsorship not specified$111k-$151kDetected 2 days ago
Project ManagementLead GenerationIntellectual PropertyPharmacologyFDA RegulatoryFlow CytometryMolecular BiologyCell CultureResearchProtein AnalysisWestern BlottingCommunicationCollaborationProblem Solving
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odds of building a lasting career here
57Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role90
Entry-level history0
PERM / green-card track0
Lottery odds (Level III)83
Fits your clock70
Sponsors, but it's cap-subject — you still face the weighted lottery (~45% per draw at Level III). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
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Files H-1B transfers
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About the role
- Research other internal team's work/experiments relevant to target identification
- May participate in patent and publication preparation
- Continually provides recommendations to improve process efficiency and research quality
Responsibilities
- Independently develop, optimize, troubleshoot and routinely execute complex biochemical and cell-based assays to evaluate small molecules, peptides and antibodies from hit-to-lead up through development candidate selection
- Support assay transfer and external studies with CROs or collaborators by executing internal bridging work, reviewing protocols and data, and troubleshooting technical issues
- An integral member of the Lead Generation Biology team that will design, optimize, execute, and troubleshoot complex biochemical and cell-based assays across multiple discovery projects.
Requirements
- MS/MA degree in scientific field and 2+ years of similar experience noted above OR
- Demonstrated ability to analyze complex data, translate experimental results into biological insights, and clearly communicate implications and recommendations to multidisciplinary project teams
- Hands-on experience with primary mammalian cell culture, including immune-relevant cells such as PBMCs or monocyte/macrophage systems and/or CNS-relevant cell types
- experience with complex or co-culture systems is desirable
- Working knowledge of cellular immunology, inflammatory signaling, and/or CNS biology, with the ability to translate biological mechanisms and hypotheses into robust, decision-enabling in vitro assays
- Working knowledge of liquid handling automation and LIMS systems
- Strong knowledge of one or more scientific disciplines, becoming expert in one discipline
- Strong knowledge of scientific principles, methods and techniques
- Ability to meet multiple deadlines, with a high degree of accuracy and efficiency
Nice to have
- PhD in biology or related field preferred and some experience similar experience noted above
- experience with flow cytometry, ELISA, HTRF, AlphaLISA, Meso-Scale Discovery (MSD), Bio-Layer Interferometry (BLI), or related technologies preferred
- BS/BA degree in scientific field and 4+ years of in vitro pharmacology experience
- Preferred experience includes: primary cell culture, especially CNS, and related assay development, liquid handling automation and LIMS systems, and related in vitro assays OR
Compensation
- The annual base salary we reasonably expect to pay is $110,800.00-$151,000.00.
Company info
- Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. ( *in collaboration with AbbVie )
- About the Role:
- An integral member of the Lead Generation Biology team that will design, optimize, execute, and troubleshoot complex biochemical and cell-based assays across multiple discovery projects. The role will have significant hands-on responsibility for establishing robust routine assays in biologically relevant cell systems, generating high-quality and reproducible data, and quantitatively analyzing and summarizing results to inform project decisions. The successful candidate will communicate findings and recommendations to biology and multidisciplinary project teams, contribute scientific insight to experimental strategy and next steps, and bring relevant subject matter expertise to the projects they support. The role works across a broad range of assay technologies/platforms and automated equipment in a collaborative and dynamic environment and contributes to process efficiency and research quality. _
- Your Contributions (include, but are not limited to):
- Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs.
- We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders.
- The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas.
- For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions.
- We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science.
- For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. ( *in collaboration with AbbVie )
- Biosciences is a leading biopharmaceutical company with a simple purpose:
- to relieve suffering for people with great needs.
- Documents research and conducts work in a safe manner in accordance with company and departmental guidelines
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