pliant-therapeutic
Senior Scientist I, Medicinal Chemistry
South San Francisco · Senior · Full-time
Sponsorship not specified$160k-$180kDetected 76 days ago
ComplianceProject ManagementIntellectual PropertyResearchLeadershipCommunication
About the role
- Pliant Therapeutics is a clinical-stage biopharmaceutical company and leader in the discovery and development of novel integrin-based therapeutics.
- Integrins are a crucial link between a cell's internal structure and its external environment and function in cell signaling, regulation and adhesion as well as wound healing and immune response.
- Pursues bold yet data-driven solutions to advance integrin-enabled therapeutics. - Make an Impact: Takes strong ownership of scientific outcomes, proactively driving decisions and progress with urgency and accountability.
Responsibilities
- Design and drive medicinal chemistry strategies for integrin-targeted therapeutics and delivery-enabled small molecules
- Utilize Structure-Activity Relationships to prioritize hypotheses, set design criteria, and guide external synthesis efforts
- Evaluate and interpret complex datasets and translate findings into clear, actionable design decisions
- Collaborate closely with biology, structural biology, DMPK, and translational teams to integrate insights into compound design and program strategy
- Prioritize and manage multiple tasks to ensure timelines and deliverables are met
- Maintain high-quality documentation and data management practices
- Our approach involves developing novel integrin-based therapeutics to treat solid tumors and other diseases.
- This role will lead the design and optimization of drug candidates that leverage integrin-mediated delivery to selectively target tissues and cell types.
- Aligns individual contributions with team and company goals to drive collective success.
- To understand how Pliant complies with and manages your personal information with respect to the California Consumer Privacy Act, please visit https://pliantrx.com/ccpa-applicant-and-staff-privacy-notice/.
Requirements
- To perform this job successfully, an individual must be able to perform each essential duty.
- The requirements listed below are representative of the knowledge, skill, abilities, and prior experience required.
- 4+ years of relevant industry experience
- Proven ability to work effectively on multidisciplinary teams in a fast-paced research environment
- Demonstrated track record of progressing compounds towards development
- Experience with antibody-drug conjugates (ADCs), linker-payload systems, or other targeted delivery modalities
- Demonstrated ability to integrate biology-driven insights into chemistry strategy, including payload selection and receptor-mediated uptake strategies
- Track record of meaningful contributions to candidate selection
- PhD in Organic Chemistry or a related discipline
- Strong foundation in synthetic organic chemistry and medicinal chemistry, with demonstrated ability to guide compound design, interpret SAR, and apply physicochemical and structural insights leading to optimized drug candidates
- Exceptional organizational and project management skills, with the ability to manage competing priorities
Nice to have
- Excellent written and verbal communication skills Preferred Qualifications
Compensation
- The annual base salary for this role is $160,000 - $180,000.
Benefits
- Pliant's compensation package also includes benefits, equity, and annual target bonus for fulltime positions.
- Launched in 2016 by Third Rock Ventures, a leading healthcare venture capital firm, Pliant has developed an industry-leading proprietary library of over 15,000 integrins that serve as a key driver to its portfolio.
- Individual pay may vary based on additional factors, including, and without limitation job-related skills, experience, work location and relevant education or training.
Company info
- Based in South San Francisco, California, Pliant was founded in 2015 to develop therapeutics to modulate specific pathways upregulated or dysfunctional in certain diseases.
- Founded by a team of world-renowned researchers from the University of California, San Francisco, this group discovered key insights into the integrin biology and developed small molecule therapeutics to target this devastating disease process.
- We believe our platform may be broadly applicable across multiple disease areas including delivery of drug payloads to cells utilizing integrin receptor-binding molecules as tissue-specific delivery and internalization mechanisms.
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