Allman Institute

Allman Institute

Senior Research Associate, Phenotypic Screening

Redwood City, CA · Senior

Sponsorship not specified$40k-$50kDetected 70 days ago
PythonData AnalysisComputer VisionExcelPharmacy PracticeBioinformaticsMolecular BiologyCell CultureResearchCommunicationCollaboration

About the role

  • This is a hands-on senior individual contributor role for someone who takes pride in operational excellence and reproducibility, and who wants their bench work to directly drive drug discovery decisions.
  • The Senior Research Associate will be a core member of the phenotypic screening team and a primary partner to the Senior Scientist in delivering reliable, decision-quality data.

Responsibilities

  • Maintain mammalian cell lines, primary cells under aseptic conditions, supporting multiple lines in parallel with consistent passage discipline.
  • Partner with the laboratory automation team to integrate assays into liquid-handling workflows and contribute to the continuous improvement of throughput and reproducibility.
  • Run basic image analysis pipelines (CellProfiler, IN Carta, Columbus, or comparable), perform plate QC, and surface anomalies for investigation.
  • Maintain meticulous electronic lab notebook entries, plate maps, reagent logs, and QC records to a standard that supports full reproducibility and traceability.

Requirements

  • Bachelor's or Master's degree in Cell Biology, Molecular Biology, Biochemistry, Bioengineering, or a closely related discipline.
  • 5-10 years of hands-on industry research experience in a drug discovery, screening, or assay development environment.
  • Proven track record running multi-step immunofluorescence or immunohistochemistry staining protocols, including multi-channel panels, surface versus permeabilized workflows, and antibody titration.
  • Meticulous documentation discipline, including electronic lab notebook proficiency, well-organized plate maps and reagent records, and a habit of full traceability.
  • Strong written and verbal communication skills, with the ability to summarize experimental results and flag issues clearly.
  • Hands-on experience operating high-content imaging systems (ImageXpress, Opera Phenix, CellInsight, or comparable), including acquisition setup and routine QC.
  • Familiarity with image analysis software (CellProfiler, IN Carta, Columbus, Harmony, or comparable) for running pipelines, plate QC, and basic data review.
  • Experience with iPSC-derived or primary epithelial cell culture (airway, alveolar, kidney epithelial, or basal keratinocyte models).
  • Experience with cell painting or other multiparametric phenotypic profiling workflows.
  • Working knowledge of basic data analysis and visualization tools (Excel, GraphPad Prism, or scripting in Python or R).
  • Required
  • Demonstrated mastery of mammalian cell culture, including parallel handling of multiple cell lines in 96- and 384-well plate formats with documented attention to sterility, passage control, and reproducibility.
  • Hands-on experience operating automated liquid handling platforms (such as Echo, Bravo, Hamilton, multidrop dispensers, or plate washers) within an assay workflow.
  • Preferred
  • Familiarity with substrate-dependent assay design and ECM coating procedures (laminin, fibronectin, collagen).

Compensation

  • $40k-$50k

Company info

  • The Allman Institute is a translational research organization applying personalized medicine to treat severe and historically difficult-to-treat diseases, beginning with pulmonary fibrosis and chronic lung transplant dysfunction.
  • The Institute combines deep molecular profiling, longitudinal clinical data, and a pragmatic mix of mechanism-guided and large-scale empirical approaches to accelerate therapeutic discovery and translation.
  • We pursue an ambitious and pragmatic, modality-agnostic therapeutic strategy spanning genetic medicines, molecular and pharmacologic therapies, cell and immune-based interventions, and engineered biological systems, in close collaboration with leading academic and biotech partners across the U.S. and abroad.
  • The Institute is established as a nonprofit, backed by substantial long-term capital committed directly to the mission.
  • Where strategically valuable, we may pursue mission-aligned for-profit ventures, spin-outs, and partnerships to accelerate therapeutic development and patient impact.
  • We are a small but rapidly growing team of approximately 20, scaling to 40-50 over the next year across labs and offices in Redwood City, CA and Cambridge, MA, driven by scientific rigor, translational urgency, and a patient-anchored mandate.
  • We are seeking a Senior Research Associate to join the phenotypic screening team and serve as a hands-on operational anchor for our high-content imaging and functional assay efforts.
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