University of Chicago

University of Chicago

Staff Scientist

Chicago, IL, USA · Staff+ · Contract

Sponsorship not specified$70k-$90kDetected 1 day ago
StatisticsBioinformaticsFlow CytometryMolecular BiologyNGSCell CultureResearchExperimental DesignAnimal StudiesCommunicationCollaboration

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odds of building a lasting career here

88Lottery-free
Cap-exempt (no lottery)100
Sponsors year-round90
Entry-level history60
PERM / green-card track50
Fits your clock70

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Files H-1B transfers

2 transfer filings in the last year, covering 2 workers. Median labor-condition decision: 8 days. An employer that already files transfers is one that can take over an existing H-1B.

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About the role

  • This is a hands-on, project-leading role with substantial scope for independent scientific direction, cross-disciplinary collaboration, and first-author publication.

Responsibilities

  • ​​Builds and expands a systematic atlas of functional antibody-receptor pairs, mapping which surface receptors yield productive antibody engagement across tumor and normal tissue contexts.
  • ​Designs and characterizes biparatopic and bispecific antibodies that improve receptor clustering, functional activity, and tumor selectivity.
  • ​Develops ligand-controlled destabilization domains to enable conditional, dose-tunable control of engineered antibody activity and reduce on-target off-tumor effects.
  • ​Designs and constructs protein and cell-based reagents, including expression constructs, engineered reporter cell lines, and stable receptor-expressing panels.
  • ​Develops and runs cell-based assays to evaluate binder candidates for functional potency.
  • ​Maintains and improves platform infrastructure, including library quality, selection protocols, standard operating procedures, and structured data records.
  • ​Analyzes next-generation sequencing outputs from selection campaigns and high-content assay datasets, with support from bioinformatics resources as appropriate.
  • Reviews laboratory protocols and training on new techniques. Manage complex data sets for research.
  • Performs other related work as needed.
  • The successful candidate will build on an established viral display platform for the selection of functional antibodies and extend it across a broad range of therapeutic antibody formats and disease targets.

Requirements

  • ​​Demonstrated experience with display-based selection (phage, yeast, or mammalian).
  • ​Proficiency in mammalian cell culture and recombinant protein expression and purification.
  • ​Experience with flow cytometry and fluorescence imaging.
  • ​Must have a record of peer-reviewed publication.
  • ​Experience engineering functional antibodies for therapeutic use
  • ​Strong experience with display-based selection technologies, including phage, yeast, and/or mammalian display, to isolate and advance antibody candidates with defined therapeutic.

Nice to have

  • ​PhD in protein engineering, immunology, molecular biology, or a related discipline.​

Skills

  • BSD RAO - Research Staff
  • About the Department

Compensation

  • $70,000.00 - $90,000.00 The included pay rate or range represents the University's good faith estimate of the possible compensation offer for this role at the time of posting.
  • The University of Chicago's Annual Security & Fire Safety Report (Report) provides information about University offices and programs that provide safety support, crime and fire statistics, emergency response and communications plans, and other policies and information.

Benefits

  • Yes The University of Chicago offers a wide range of benefits programs and resources for eligible employees, including health, retirement, and paid time off.
  • Information about the benefit offerings can be found in the Benefits Guidebook.

Company info

  • Department BSD RAO - Research Staff About the Department ​​The Jie Zhou lab is part of Department of Radiation Oncology at the University of Chicago.
  • We are seeking a highly motivated scientist to lead the discovery and engineering of functional antibodies for therapeutic applications.

Equal opportunity

  • Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form.
  • Job seekers in need of a reasonable accommodation to complete the
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