Twist Bioscience
Protein Scientist
USA - Portland, OR
Sponsorship not specifiedDetected 32 days ago
PythonSQLBioinformaticsMolecular BiologyProtein AnalysisCommunicationProblem Solving
About the role
- The primary focus of this role will be affinity and kinetics measurements of antibody/antigen interactions using SPR.
- You will also be expected to assist manufacturing associates in troubleshooting experiment issues as they arise.
- This role provides the opportunity to work cross-functionally with R&D scientists, automation & software engineers, and bioinformaticists in a fast-paced, innovation-driven company.
Responsibilities
- Perform and analyze affinity and kinetics measurements of antibodies produced in our high-throughput production facility
- Implement and troubleshoot workflows for biophysical and functional characterization of IgG and VHH, including analytical SEC, DLS, DSF, HIC, and additional downstream assays as needed.
- Serve as technical lead for protein characterization and help train and assist manufacturing assistants with execution of assays
- Author technical documents, protocols, training guides, and validation reports to ensure smooth process implementation and knowledge transfer.
- Collaborate in cross-functional project teams representing protein characterization in core team meetings and contributing to strategic decisions.
- Document work in electronic lab notebooks and communicate results to stakeholders clearly and regularly.
Requirements
- And Required Skills
- Experience with various high-throughput automation platforms.
- Ph.D. in Protein Chemistry, Biochemistry, Molecular Biology, or a related field, or M.S. with 2-5 years of relevant industry experience.
- Strong hands-on experience in protein purification and characterization techniques.
- Experience characterizing affinity/kinetics (KD, ka, kd) of protein/target interactions using SPR or BLI
- Familiarity with biophysical methods for antibody developability such as SEC, DLS, DSF, HIC, ac-sins, enzymatic activity assays, among others.
- Excellent problem-solving skills, scientific judgment, and attention to detail.
- Strong interpersonal and communication skills with the ability to work in a collaborative, cross-disciplinary environment.
- Ability to troubleshoot, train, and mentor others in experimental workflows and data interpretation
- Ability to multitask and thrive in a fast-paced and challenging environment.
- Work cross-functionally within and across the department effectively as a team player.
- Excellent problem-solving capabilities.
Nice to have
- Background in protein chemistry and experience characterizing antibodies is strongly preferred.
- Preferred Skills
Company info
- At Twist Bioscience, we work in service of people who are changing the world for the better.
Equal opportunity
- Twist Bioscience Corporation is an Equal Opportunity Employer.
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