Novartis

Novartis

Principal Scientist I, Soluble Biomarkers- Molecular & Cellular Sciences (MCS)

Cambridge (USA) · Principal

Sponsorship not specifiedDetected 12 days ago
PythonMachine LearningData AnalysisData ScienceInventory ManagementClinical TrialsCRISPRMolecular BiologyResearchMass SpectrometryProtein AnalysisLeadershipCommunicationCollaborationProblem Solving

About the role

  • The salary for this position is expected to range between: $108,500 and $201,500 per year.
  • The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically.
  • Novartis may change the published salary range based on company and market factors.

Responsibilities

  • Develop, validate, and implement immunoassay- and LC-MS-based methods to quantify exploratory soluble biomarkers for clinical programs across the Novartis portfolio, with a primary focus on neuromuscular and muscle disease programs.
  • Apply hands-on assay development expertise to build robust, fit-for-purpose biomarker methods that support clinical decision-making and advance translational science objectives.
  • Serve as the scientific and technical lead for exploratory soluble biomarker assays, including assay strategy, data quality, interpretation, documentation, and alignment to context of use and clinical study endpoints.
  • Evaluate and implement innovative assay technologies and workflows to improve assay sensitivity, specificity, reproducibility, throughput, and biological relevance for neuromuscular indications.
  • Analyze, interpret, and communicate biomarker and assay data to key stakeholders, project teams, and cross-functional stakeholders to support timely, evidence-based decisions.
  • Partner with internal line functions and external vendors to deliver high-quality fit-for-purpose biomarker assays, and sample analysis activities within agreed timelines.
  • Maintain high standards for scientific rigor, documentation, data integrity, compliance, safety, and technical excellence in accordance with applicable Novartis policies and procedures.
  • Strong hands-on experience developing, optimizing, validating, and troubleshooting immunoassays (ELISA, MSD, Luminex, Simoa) and LC-MS methods of varying complexity for soluble biomarkers.
  • Demonstrated ability to design rigorous experiments, solve complex technical problems, assess assay performance, and communicate conclusions clearly to scientific and non-scientific stakeholders.

Requirements

  • PhD with 2+ years of experience in drug discovery, translational research, or related field
  • or Master's degree with 10+ years of experience in the pharmaceutical/ biotech industry.
  • Experience with tissue biopsies, particularly muscle tissue, and associated assays or workflows such as IHC/IF, tissue collection, processing, and sample handling best practices.
  • Solid experience supporting neuromuscular, muscle, or related disease biology programs, with the ability to connect assay strategy with the biomarker plan.
  • Experience working in cross-functional project teams and managing internal or external assay development activities, timelines, deliverables, and scientific documentation.
  • Excellent oral and written communication skills, including the ability to present scientific strategy, data, risks, and recommendations clearly.
  • Experience with genomic, transcriptomic, proteomic, or other multi-omics approaches, including RNA-seq or related platforms.
  • Strong understanding of circulating muscle proteins, including structural and functional biomarkers relevant to muscle disease biology.

Compensation

  • $108,500.00 - $201,500.00
  • $108,500 and $201,500 per year.
  • The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically.
  • Novartis may change the published salary range based on company and market factors.
  • Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

Benefits

  • US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits.
  • In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.
  • To learn more about the culture, rewards and benefits we offer our people click here.

Equal opportunity

  • The Novartis Group of Companies are Equal Opportunity Employers.
  • Accessibility and reasonable accommodations
  • The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities.
  • Please include the job requisition number in your message.
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This listing is sourced directly from Novartis's careers page and normalized into a canonical job model.