AbbVie
Senior Scientist I, Cell Line Development
South San Francisco, CA, United States · Senior
Sponsorship not specifiedDetected 1 day ago
PythonData AnalysisAccessibilityClinical TrialsClinical Laboratory TechniquesGMPBioinformaticsqPCRCRISPRFlow CytometryMolecular BiologyNGSCell CultureExperimental DesignLeadershipCommunication
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Entry-level history0
PERM / green-card track0
Lottery odds40
Fits your clock70
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About the role
- The Biologics CMC Development organization at AbbVie has a long and rich history of biologics development, leveraging comprehensive end-to-end CMC capabilities to advance complex biologic therapies, such as bi-specifics and novel modalities, from discovery through human clinical studies and eventual licensure.
- The Cell Line Development (CLD) Innovation Group is seeking a Senior Scientist I to join a talented and collaborative team developing next-generation CHO cell line platforms for the production of recombinant antibodies and complex biologics.
- This is a hands-on, laboratory-focused role for a versatile molecular biologist who will independently drive expression-optimization projects across both the vector and the host cell - from experimental design through execution and data interpretation.
Responsibilities
- Independently conceive ideas and designs to investigate CHO expression technical improvements across both vector and host cell.
- Design and test dozens of vector constructs in recombinant stable CHO cell lines for increased mAb titer.
- Collaborate closely with cell culture, analytical, purification, and bioinformatics colleagues to meet project timelines, and adhere to corporate standards for code of conduct, safety, materials handling, and good documentation practices.
- Demonstrated ability to read the literature, review external sources, and gather inputs to synthesize technically sound ideas and design proper experimental controls.
- Candidates with substantial experience developing CHO expression platform improvements in an industrial/CMC setting.
Requirements
- the role spans the full set of levers that govern expression, and the candidate is expected to think, read, and propose, then carry the work out at the bench with a high degree of independence.
- Senior Scientist I: BS with a minimum of 10 years, or MS with a minimum of 8 years of experience, or PhD with no minimum years' experience, in molecular biology, cell biology, biochemistry, or a related discipline.
- Demonstrated proficiency with designing and implementing vector improvements to increase recombinant antibody expression levels in stable CHO cells.
- Proficiency with Geneious Prime or similar software for designing and annotating DNA vectors, primers, and probes, and performing sequence alignments.
- Proficiency with cell engineering to knock in / knock out target genes using CRISPR/Cas or other suitable tools.
- Strong scientific communication skills - verbal, written, and data presentation - with detailed daily digital lab notebook record-keeping proficiency.
Benefits
- AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow.
- We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
Company info
- We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio.
Equal opportunity
- Employer/Veterans/Disabled.
- US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
- US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
- https://www.abbvie.com/join-us/reasonable-accommodations.html
This listing is sourced directly from AbbVie's careers page and normalized into a canonical job model.