Generate Biomedicines

Senior Director, Protein Analytics & Biophysics

Somerville, MA · Director

Sponsorship not specifiedDetected 50 days ago

Machine LearningStatisticsA/B TestingPharmacy PracticeMolecular BiologyMass SpectrometryAnimal StudiesLeadershipCommunicationCollaborationMentoring

About the role

Define the next generation of biophysical, biochemical, developability, and protein-protein interaction measurement capabilities for protein therapeutics, with a particular focus on miniaturized, pooled, high-throughput, and nanoscale approaches.
Establish data standards, quality expectations, assay controls, and analytical frameworks that allow high-throughput measurements to be used confidently for model training, candidate triage, and program decision-making.
Ensure the function generates high-quality, decision-enabling data across Discovery, Candidate Selection, and early Development, including developability, stability, specificity, affinity, kinetics, and manufacturability-relevant attributes.

The right person will be energized by the challenge of connecting micro- and nanoscale assay innovation with Generate's AI/ML-enabled protein design engine.
Drive operational excellence across the function, including prioritization, resource planning, milestone delivery, metrics, continuous improvement, and clear communication of tradeoffs.
Build, coach, and develop a high-performing team of managers, senior scientists, and technical experts, creating clear growth paths and succession strength within the function.
Develop leadership capability across the organization by mentoring managers, growing future leaders, and strengthening Generate's broader scientific culture.
Manage external collaborations, CRO strategy, academic relationships, vendor partnerships, and technology scouting efforts that increase scale, speed, and scientific differentiation.
Generate:Biomedicines is seeking a scientifically bold, highly collaborative Senior Director to lead Protein Analytics & Biophysics within our Therapeutics division.
This role will own the continued excellence of conventional protein analytics, developability, and protein-protein interaction technologies while building the next generation of at-scale experimental systems.

Ph.D. in Biophysics, Biochemistry, Molecular Biology, Chemical Biology, Bioengineering, Synthetic Biology, Protein Engineering, or a related scientific discipline
or equivalent depth of industry experience.
Deep technical expertise across conventional analytical and biophysical methods, such as HPLC/UPLC (SEC, RP, HIC, IEX), LC/MS, CE-SDS, cIEF, DSF, DSC, DLS, SEC-MALS, SPR, BLI, and related technologies.
Strong understanding of protein-protein interaction measurement, including affinity, kinetics, specificity, cross-reactivity, epitope/binning, avidity, and context-dependent binding behavior.
Strong quantitative mindset and experience using data quality, assay statistics, modeling, and informatics to shape scientific strategy, technology investment, and operational decision-making.
Experience partnering closely with prototyping, automation, engineering, computational, and technology teams to translate exploratory assay concepts into robust, reproducible, and scalable capabilities.
Exceptional collaboration and communication skills, with a clear track record of influencing across complex, matrixed organizations and engaging executive stakeholders with clarity, candor, and credibility.
Experience advancing biologics programs across Discovery and early Development, with an understanding of developability considerations, candidate selection, and downstream impact.

Set and drive the multi-year scientific and organizational vision for Protein Analytics & Biophysics, aligning functional strategy with Generate's platform, portfolio, and company priorities.

This listing is sourced directly from Generate Biomedicines's careers page and normalized into a canonical job model.