Xaira Therapeutics
Principal Scientist, Functional Genomics
South San Francisco, California, United States · Principal
Stay score
odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
$6,501 more — $181,501 — moves this role to Level IV and 4 lottery entries. That figure is inside the range the employer already advertised.
Based on the DOL prevailing wage for this occupation and worksite, a base salary of $181,501 would place this position at wage Level IV. That figure is within the posted range, and I'd like to target it. This role classifies under "Medical Scientists, Except Epidemiologists" for prevailing-wage purposes.
DOL prevailing wage, 2026-27 wage year · Medical Scientists, Except Epidemiologists (19-1042) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
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About the role
- Xaira is seeking a highly motivated and experienced Principal Scientist to join our Functional Genomics team with a focus on high-throughput perturbation platforms and single-cell genomics technologies.
- This position offers the opportunity to contribute to cutting-edge efforts at the intersection of functional genomics, machine learning, and disease biology.
- Present scientific findings and contribute to publications, patents, and scientific presentations while mentoring and providing scientific guidance to researchers within the organization
Responsibilities
- Lead high-throughput perturbation and functional genomics efforts supporting therapeutic discovery and AI/ML-driven research initiatives
- Develop and implement advanced functional genomics technologies, including perturb-seq, CRISPRi/a, and single-cell omics workflows across complex cellular systems such as primary cells, differentiated cell types, and in vivo models
- Design, optimize, and scale screening workflows to improve throughput, reproducibility, data quality, and experimental robustness
- Collaborate closely with AI/ML scientists, computational biologists, automation engineers, and disease biology teams to integrate large-scale perturbation datasets into predictive modeling frameworks
- Contribute to scientific strategy, experimental design, protocol development, and prioritization across multiple programs and platform initiatives
- Our goal to build a diverse and inclusive team began on day one, and it will never end.
Requirements
- Ph.D. in Immunology, Genomics, Molecular Biology, Bioengineering, or related scientific discipline with 10+ years of relevant industry and/or applied research experience
- Experience generating, analyzing, and interpreting large-scale perturbation datasets across complex cellular systems including primary cells, differentiated models, and organoid systems
- Familiarity with AI/ML applications in functional genomics and experience collaborating closely with computational and data science teams
- Excellent analytical, organizational, written, and verbal communication skills, with the ability to thrive in fast-paced, highly collaborative environments focused on scientific innovation
- Deep expertise in CRISPR-based screening approaches, perturb-seq, and single-cell RNA sequencing technologies, with a strong track record developing and scaling high-throughput functional genomics platforms
- Demonstrated ability to independently lead scientific initiatives, drive cross-functional collaboration, and mentor scientists within multidisciplinary research environments
Skills
- About Xaira Therapeutics
- Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development.
- Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development.
- Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.
Compensation
- We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers.
- We offer a competitive package that includes base salary, bonus, and equity.
- The base pay range for this position is expected to be $175,000 - $205,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.
Benefits
- A Summary of Benefits is available for all applicants.
This listing is sourced directly from Xaira Therapeutics's careers page and normalized into a canonical job model.