Manifold Bio
Scientist, mRNA/cDNA/Cell-Free Display
Boston
Sponsorship not specified$118k-$138kDetected 16 days ago
Full-Stack DevelopmentMachine LearningMolecular BiologyLab ResearchAnimal Studies
About the role
- Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.
- You will work at the intersection of protein engineering, laboratory automation, and ML-guided drug discovery, collaborating closely with our binder discovery, ML, and automation teams.
- We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.
Responsibilities
- Design, develop, and validate a cell-free display platform (cDNA display or similar) compatible with diverse binder formats
- Collaborate with ML and computational teams to ensure screening outputs feed effectively into model training pipelines
- Work with the protein engineering team to support discovery campaigns and affinity maturation as platform capacity allows
- Stay current on advances in cell-free display, laboratory automation, and computational protein design
- Strong molecular biology fundamentals and demonstrated ability to develop and troubleshoot complex, multi-step workflows
Requirements
- PhD or equivalent experience in protein biochemistry, molecular biology, biological engineering, or a related field
- Hands-on experience with cell-free selection systems (cDNA display, mRNA display, ribosome display, or similar)
- Experience with or strong interest in laboratory automation
Nice to have
- Track record of successfully automating complex laboratory workflows
- Background in therapeutic antibody discovery or protein engineering
- Experience with computational protein design
- Familiarity with how high-throughput screening data feeds into ML and computational pipelines
- Experience with complex or non-traditional binder formats and biochemical intuition to adapt selection workflows accordingly
- You are energized by working at the intersection of wet lab science, automation, and AI-driven biotherapeutic discovery
- You are a collaborative scientist who communicates well across teams with different technical backgrounds
- Why you might be a good fit
Compensation
- Final compensation decisions are made using a consistent leveling framework and consider the candidate's experience, interview performance, and expected impact.
- $118,000-138,000
- Annual performance-based target bonus
- Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.
Benefits
- Annual performance-based target bonus
- Comprehensive medical, dental, and vision coverage
- Flexible paid time off and holidays
- This reflects the typical offer range for this role, based on experience, role scope, and internal equity.
- Perks including on-site gym, onsite lunch, and commuter support
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