Madrigal Pharmaceuticals

Director, IT Enterprise Architect

PA - Conshohocken - Office, USA · Director · Full-time

Sponsorship not specified$214k-$261kDetected 27 days ago

AzureCRMCompensationFDA RegulatoryCommunicationMentoringPublic SpeakingGxP

About the role

Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.
Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3).
An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Orchestrate the creation, alignment, and rollout of IT-wide architecture standards and reference patterns with technical domain leads, ensuring consistent enterprise adoption.
Drive a shared set of "minimum viable architecture" expectations for common solution types by aligning domain owners and ensuring consistent usage through checkpoints and exception handling.
Build and maintain Madrigal's enterprise capability model and use it as the primary language for technology strategy, prioritization, and alignment.
Map key platforms, data, and integrations to business capabilities to create clear line-of-sight from strategy to capability to technology decisions.
Drive modernization and rationalization recommendations that reduce fragmentation and technical debt while enabling business outcomes.
Partner with Strategy & Operations, Infra/Ops, and Data/AI leaders to align roadmaps and sequencing across domains.
Engage directly with delivery teams to shape solution designs early, resolve tradeoffs, and prevent rework late in the lifecycle.
Support high-priority initiatives as a working architect (workshops, design sessions, integration patterns, data flows), especially where the enterprise impacts are highest.
Increase reuse by steering teams toward shared platforms, standard patterns, and approved building blocks.
Partner with PMs and program leaders to ensure architecture decisions, risks, and exceptions are visible, decisioned, and tracked.

Bachelor's degree in Computer Science, Information Systems, Engineering, or a related technical field (or equivalent practical experience).
12+ years of relevant experience with 5+ years in biotech/pharma (regulated/GxP), building compliant-by-design architectures.
Experience in high-growth environments
Deep experience with Veeva platform(s) and integration into the broader enterprise ecosystem.
Proven track record architecting AI-enabled solutions, including data foundations and scalable deployment patterns.
Demonstrated ability to influence executives with clear options, tradeoffs, and decision-ready recommendations.
Educational Requirements:
TOGAF or comparable certification
Nice-to-have qualifications include the following:
Microsoft certifications in Azure architecture and/or Power Platform solution architecture
Recognized cybersecurity architecture credential (e.g., Microsoft SC-100, CISSP, or CCSP)
Veeva certifications spanning both Commercial and R&D/Quality domains (Vault CRM, RIM, Trial Master, Quality)
CSV/CSA credential demonstrating validation readiness in regulated environments.
comfortable as a hands-on architect who drives outcomes, not just documents.

Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity.

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality.

This listing is sourced directly from Madrigal Pharmaceuticals's careers page and normalized into a canonical job model.