Profound Research
Principal Investigator- Vaccines (Oceanside, CA)**
Oceanside, CA · Principal
Sponsorship not specifiedDetected 65 days ago
GCPComplianceClinical TrialsClinical ResearchFDA RegulatoryResearchLeadership
About the role
- We handle all infrastructure, regulatory compliance, and administrative operations so physicians can focus on patient care.
- Our model gives patients access to the newest therapies while maintaining the trusted patient-physician relationship.
- Why This Role Exists At Profound Research, the Principal Investigator is the clinical cornerstone of everything we do at the site level.
Responsibilities
- Maintain a thorough working knowledge of each protocol - including visit schedules, endpoint criteria, and investigational product requirements - and ensure the trial is conducted accordingly
- Ensure data accuracy and completeness across case report forms and source documents, and support the site's readiness for monitoring visits and audits
- Collaborate effectively with sponsors, the IRB, and the Profound Research team throughout the life of the trial
- Proven ability to lead and collaborate with a multi-disciplinary clinical research team
- We embrace challenges with a positive mindset, communicate directly, and identify and implement effective solutions with efficiency.
- We insist on excellence, holding ourselves accountable and empowering each other to deliver best-in-class service while maintaining the highest ethical and scientific standards.
- We actively support internal growth and create pathways for people to take on greater responsibility over time
- Diverse Clinical Exposure: Work across multiple therapeutic areas and study phases, building a breadth of experience that's rare in a single organization
Requirements
- Prior experience conducting clinical research, with working knowledge of ICH/FDA/GCP guidelines and regulatory requirements
- Oversee informed consent, adverse event documentation, and all required safety reporting to the sponsor and IRB
Nice to have
- Established relationships with community physicians or patient populations in the San Diego area
- Familiarity with CTMS platforms and electronic data capture systems
- Requires the ability to communicate clearly in verbal and written forms and to read and interpret detailed materials
- Must be able to navigate a clinical facility, including areas with limited space, and transport supplies or work materials as needed
- May be required to wear personal protective equipment (PPE) in accordance with facility protocols
- Physical Requirements & Work Environment
- Why Join Profound Research?
- Leadership & Advancement: Profound is a place where initiative is recognized.
Compensation
- Full Benefits Package: Competitive compensation, health insurance, PTO, retirement plan, and professional development support
Benefits
- Competitive compensation, health insurance, PTO, retirement plan, and professional development support
- MD or DO with an active, unrestricted California medical license
- We invest in our people through comprehensive training, certification support, and ongoing education to help you grow in your role and your career
Company info
- Improving Lives by Providing Advanced Therapeutic Options
- Our Vision: Creating the Absolute Best Patient-Physician Experience in Clinical Research
- Compassion: We prioritize the patient-physician relationship, ensuring every interaction is service-oriented and patient-centered.
- Urgency: We work hard and practice selflessness, acting swiftly and decisively to meet the needs of our patients, partners, and colleagues.
- Solution Orientation: We embrace challenges with a positive mindset, communicate directly, and identify and implement effective solutions with efficiency.
- Excellence: We insist on excellence, holding ourselves accountable and empowering each other to deliver best-in-class service while maintaining the highest ethical and scientific standards.
- Why This Role Exists
- At Profound Research, the Principal Investigator is the clinical cornerstone of everything we do at the site level.
- In this role, you'll provide the medical expertise and oversight that makes safe, high-quality research possible - evaluating participants for eligibility, directing the conduct of the trial, and ensuring every decision reflects both scientific rigor and genuine care for the people who trust us with their participation.
- You'll also serve as a direct extension of the trusted patient-physician relationship that sits at the heart of our model: participants aren't just enrollees, they're patients, and they deserve a physician who treats them that way.
- This is a role for a physician who wants to be genuinely present in the work - one whose judgment, accountability, and commitment to patients directly shape the integrity and success of the research.
- You'll work alongside a team of dedicated professionals who are passionate about clinical research and committed to doing it well
Visa & Work Authorization
- Oversee informed consent, adverse event documentation, and all required safety reporting to the sponsor and IRB
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This listing is sourced directly from Profound Research's careers page and normalized into a canonical job model.