City Therapeutics

Senior Scientist, CMC Quality Control

Cambridge, MA · Senior · Full-time

Sponsorship not specified$136k-$154kDetected 77 days ago

Mass SpectrometryCommunicationProblem Solving

About the role

City Therapeutics is seeking a passionate Senior Scientist, CMC Quality Control to join our growing team.
The current focus will be on release and stability management of oligonucleotide drug substances, drug products, and process intermediates (e.g., siRNA and conjugates).
This role will report to the Senior Director, CMC AD/QC and contribute directly to City's next-generation siRNA programs.

Lead method verification/qualification, validation (as needed), and method transfer for existing and new programs.
Manage stability protocols and reports from partners
Write CMC source documents such as, but not limited to, analytical methods, qualification/validation protocols and reports
Operate, calibrate, maintain, and troubleshoot analytical instrumentation; ensure adherence to data integrity and safety practices.

Familiarity with cGxP expectations, analytical data systems, and data integrity principles.
Meticulous documentation, strong problem-solving, and the ability to operate with minimal supervision.
Demonstrated skills in handling, analyzing, and characterizing oligonucleotides and related organic molecules.
Knowledge of CMC regulatory requirements (e.g., IND/IMPD) is a plus.
Understanding of basic theories and principles of synthetic organic chemistry is a plus
Excellent communication, organization, and teamwork skills
comfortable in a fast-paced, multi-project environment with shifting priorities.

Conduct exploratory stability studies for raw materials, intermediates, DS, and DP
interpret trends and recommend actions.
Work both independently and with cross-functional teams to plan, prioritize, and meet project timelines.
ensure adherence to data integrity and safety practices.
Ph.D. in Analytical Chemistry or related field with 3+ years relevant industry experience
M.S. with 7+ years
or B.S. with 10+ years.
CDMO experience is highly valued.

The base salary range provided reflects our current estimate of what we anticipate paying for this position.
Your actual base salary will be based on several factors, including relevant skills, experience, internal equity, relevant education or training and market dynamics.
In addition, this role is eligible for an annual cash bonus and equity compensation.
Per Year Salary Range: $136,000 to $154,000.
City Therapeutics is accepting resumes/CVs from direct applicants only. Recruitment agency submissions will not be accepted at this time.
national origin

City Therapeutics is an Equal Opportunity and Affirmative Action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race
City Therapeutics is an Equal Opportunity and Affirmative Action employer committed to a culturally diverse workforce.

This listing is sourced directly from City Therapeutics's careers page and normalized into a canonical job model.