Insitro

Scientist II, Arrayed Screening

South San Francisco, CA · Mid

Sponsorship not specified$136k-$145kDetected 60 days ago

PythonMachine LearningData AnalysisData ScienceLLMsPharmacologyqPCRCRISPRFlow CytometryMolecular BiologyCell CultureCommunicationOrganizational Skills

About the role

The unprecedented convergence of multi-modal data and AI has the potential to revolutionize drug discovery. insitro is harnessing this moment to redefine how medicines are developed for complex diseases.
insitro is seeking a highly motivated Scientist II, Arrayed Screening to join our experimental biology and screening organization.
This is a highly collaborative role at the interface of cell biology, assay development, automated screening, disease modeling, and machine learning.

Responsibilities

Develop, optimize, and execute arrayed screening assays in 96- and 384-well plate formats, including endpoint, kinetic, imaging-based, and/or biochemical readouts.
Design and implement cell-based screening workflows using immortalized, primary, iPSC-derived, or engineered cellular models.
Support small-molecule, genetic, and/or perturbational screening efforts, including assay development, target validation, mechanism-of-action studies, and screening campaigns.
Partner with automation and process engineering teams to scale assays using liquid handlers and screening platforms such as Echo, Hamilton, Bravo, Tecan, or similar systems.
Collaborate with ML and data science teams to ensure experiments generate reproducible, well-annotated, model-ready datasets.
Work cross-functionally with disease biology, genetics, cell modeling, and drug discovery teams to translate biological questions into scalable experimental designs.
Maintain rigorous documentation in Benchling/LIMS systems and contribute to best practices for assay robustness, reproducibility, and data quality.
PhD in cell biology, molecular biology, biochemistry, pharmacology, bioengineering, chemical biology, or related fields. 2-5 years of relevant post-PhD or equivalent industry experience, with demonstrated independence in assay design and project leadership.
Strong hands-on experience developing and running cell-based assays in high-throughput plate formats.

Nice to have

PhD in cell biology, molecular biology, biochemistry, pharmacology, bioengineering, chemical biology, or related fields.
Experience with high-content imaging, fluorescence/luminescence assays, viability assays, reporter assays, immunostaining, flow cytometry, or other quantitative cellular readouts.
Strong mammalian cell culture skills, including aseptic technique and experience with immortalized, primary, stem-cell-derived, or engineered cell systems.
Familiarity with molecular biology approaches such as cloning, CRISPR/gene editing, transgene expression, stable cell line generation, qPCR, or related methods.
Experience with screening automation and liquid handling platforms is strongly preferred.
Comfortable working with small molecules, biologics, siRNA/ASO, CRISPR reagents, or other perturbation modalities.
Ability to analyze, interpret, and clearly communicate complex biological datasets.
Experience with GraphPad Prism, Spotfire, Benchling, Python, or R.

Compensation

Our target starting salary for successful US-based applicants for this role is $136,000 - $145,000.
To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity.
We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
In addition, insitro also provides our employees:
401(k) plan with employer matching for contributions

Benefits

To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity.
Excellent medical, dental, and vision coverage as well as mental health and well-being support
Open, flexible vacation policy
Paid parental leave of at least 16 weeks to support parents who give birth, and 10 weeks for a new parent (inclusive of birth, adoption, fostering, etc)
New hire stipend for home office setup
Monthly cell phone & internet stipend

Equal opportunity

insitro is an equal opportunity employer.

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This listing is sourced directly from Insitro's careers page and normalized into a canonical job model.