Twist Bioscience
Sr Bioinformatics Scientist
USA - South San Francisco, CA · Senior
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odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~45% per draw at Level III). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
$12,742 more — $147,742 — moves this role to Level III and 3 lottery entries. That figure is inside the range the employer already advertised.
Based on the DOL prevailing wage for this occupation and worksite, a base salary of $147,742 would place this position at wage Level III. That figure is within the posted range, and I'd like to target it. This role classifies under "Biological Scientists, All Other" for prevailing-wage purposes.
DOL prevailing wage, 2026-27 wage year · Biological Scientists, All Other (19-1029) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
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Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.
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About the role
- Senior Bioinformatics Scientist Position Overview Twist Bioscience is seeking a Senior Bioinformatics Scientist to join our Scientific Computing team supporting R&D across DNA Synthesis and Protein Solutions.
- About Twist Bioscience Twist Bioscience synthesizes genes from scratch, known as "writing" DNA.
Responsibilities
- Develop novel computational methods and algorithms supporting DNA synthesis, sequence analysis, and protein characterization.
- Partner with experimental scientists to formulate hypotheses, design experiments, and interpret results that guide product and process development.
- Evaluate and validate analytical approaches, including their accuracy, limitations, and applicability across experimental conditions.
- Develop reproducible analysis pipelines using Nextflow and other scientific computing tools to support research and method evaluation.
- Communicate findings and recommendations to scientific and cross-functional stakeholders, and collaborate with engineers to translate successful methods into broader use.
Requirements
- Ph.D. with 3+ years, Master's degree with 6+ years, or Bachelor's degree with 8+ years of relevant experience in bioinformatics, computational biology, biostatistics, or a related field
- Strong Python programming skills and experience analyzing biological or experimental data.
- Hands-on experience with NGS analysis and a solid understanding of molecular biology.
- Demonstrated ability to independently investigate scientific problems and learn unfamiliar methods or biological domains.
Nice to have
- Experience with protein data analysis, DNA synthesis, or sequence design.
- Experience working with high-throughput experimental datasets and integrating multiple data types.
- Familiarity with cloud computing and scalable scientific workflows.
- We welcome candidates with depth in a relevant scientific area and the curiosity and quantitative foundation to contribute across disciplines.
- About Twist Bioscience
- Twist Bioscience synthesizes genes from scratch, known as "writing" DNA.
- Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.
- Twist Bioscience Corporation is an Equal Opportunity Employer.
Compensation
- San Francisco Bay Area Pay Range
Benefits
- Apply statistical methods, machine learning, and predictive modeling to connect sequence and experimental features with product quality and performance.
Company info
- We are looking for a curious scientist with strong computational skills and sound scientific judgment who enjoys learning new biology and turning open-ended questions into actionable insights.
- At Twist Bioscience, we work in service of people who are changing the world for the better.
- In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.
This listing is sourced directly from Twist Bioscience's careers page and normalized into a canonical job model.