Prolific Machines

Analytical Scientist I

Emeryville, California

Sponsorship not specified$120k-$140kDetected 21 days ago

A/B TestingMolecular BiologyCell CultureMass SpectrometryCommunication

About the role

Prolific Machines is ushering in a new era of biotechnology with light.
Prolific is supported by leading investors, including Bill Gates's Breakthrough Energy Ventures, Mayfield, and SOSV.
The Analytical Science team is looking for a talented scientist to collaboratively work with our R&D and Bioprocess teams to quantify and characterize broad classes of therapeutic proteins.

Develop, optimize, and validate assays for protein quality and purity for broad classes of recombinant therapeutic proteins.
Qualify and validate assays upholding highly rigorous standards for execution and documentation.
Routinely operate, maintain, and troubleshoot analytical instrumentation (HPLCs, FPLCs, mass spectrometers).
Author, review, and implement methods, protocols, validations, and standard operating procedures.
Have illustrated the ability to develop, execute, and interpret intact mass, sequence confirmation, and PTM analysis (e.g., glycosylation, disulfide mapping, peptide mapping) through mass spectrometry.
Have illustrated the ability to develop, execute, and interpret aggregation and charge variant characterizations for biologics.
Are highly motivated to deliver successful outcomes for internal and external clients.
Are excited to work with internal and external clients to deliver project excellence.
We are committed to building an inclusive workplace where all employees can bring their authentic selves to work and have equal opportunities to succeed.

Plan and execute experimentation to understand protein quality through cell line, upstream and downstream process development.
Execute, summarize, and interpret routine and complex therapeutic protein characterizations.
Ensure processes are followed in accordance with these standards.
Hold a PhD in Analytical Chemistry, Molecular Biology, Biochemistry, Pharmaceutical Sciences, with 1+ years of biologics industry experience.
Have illustrated experience in therapeutic protein characterization approaches (eg.
HPLC, SDS, CE, cIEF, LC-MS).
Have experience in the development and execution of GLP-compliant methods characterizing protein quality attributes across a wide range of therapeutic classes.
Have hands-on experience operating LC-MS.

Prolific Machines values diverse perspectives, backgrounds, experiences, and ideas.
Prolific Machines is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, religion, creed, sex, gender identity or expression, sexual orientation, national origin, ancestry, age, disability, medical condition, genetic information, marital status, military or veteran status, or any other characteristic protected by applicable law.

This listing is sourced directly from Prolific Machines's careers page and normalized into a canonical job model.