Amylyx Pharmaceuticals

Senior Director, External Manufacturing

Cambridge, MA · Director

Sponsorship not specified$245k-$276kDetected 15 days ago

Stakeholder ManagementSupply ChainRecruitingGMPLeadershipCommunication

About the role

The Senior Director, External Manufacturing is a critical leadership role responsible for shaping and executing the external manufacturing strategy across clinical and future commercial programs.
As Amylyx advances toward commercialization and expands its global manufacturing footprint, this role will be instrumental in ensuring supply continuity, operational readiness, and long-term scalability.

Define and execute manufacturing strategies to support technology transfer, scale-up, commercialization, and lifecycle management
Mentor and build a team of relationship owners responsible for leading the internal supplier relationship teams and serving as the supplier point of contact
Ensure supply continuity through proactive risk identification, mitigation planning, and issue escalation across external partners
Support commercial launch readiness, including validation, supply planning, and inspection preparedness
Partner cross-functionally with Finance, Legal, CMC, Quality, and Supply Chain to drive aligned execution
Build scalable, robust external manufacturing infrastructure, operating models, and governance frameworks to support organizational growth

~15+ years of experience in pharmaceutical or biotechnology manufacturing, including significant external manufacturing leadership
Proven track record managing CDMOs across clinical and commercial supply environments
Experience in manufacturing strategy, technology transfer, and commercialization activities
Experience across multiple supply nodes (API, Drug Product, Packaging, Device)
Ability to travel domestically and internationally ~10%
Experience across multiple modalities (small molecule, peptide, oligonucleotide)
A track record of process scale-up, validation and continuous improvement

The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks.
Estimated Pay Range
$245,000 - $276,000 USD
Amylyx's management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment.

The final offer may vary depending on a candidate's experience, skills, and qualifications, as well as considerations of internal equity.

If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related condition

This listing is sourced directly from Amylyx Pharmaceuticals's careers page and normalized into a canonical job model.