Spyre Therapeutics

Vice President, Clinical Development

US- Remote · Exec

Sponsorship not specified$366k-$398kDetected 14 hours ago

Clinical TrialsFDA RegulatoryLeadershipCollaborationMentoringBiostatisticsRegulatory Affairs

About the role

Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.
The expected salary range offer for this role is $366,000 to $398,000.
Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location.

Develop and continuously refine integrated clinical development plans aligned with corporate objectives, competitive landscape, and evolving scientific insights.
Serve as a hands-on study lead for the current platform trial as well as contribute to planning pivotal studies.
Lead protocol development, study conduct, data review, and interpretation for ongoing clinical trials, partnering closely with clinical operations, regulatory, biometrics, etc., to ensure successful execution.
Drive key development decisions through analysis of emerging clinical, translational, safety, and competitive data.
Support signal detection, risk management planning, and clinical risk mitigation strategies.
Lead and mentor a high-performing clinical development team as the company grows.

Minimum of 7+ years clinical development experience within the pharmaceutical or biotech industry, including substantial leadership experience in immunology, inflammation, or gastroenterology.
Training and/or experience in clinical development in gastroenterology or immunology & inflammation is strongly preferred.
Demonstrated success leading mid- and late-stage clinical development programs.
Experience leading complex, adaptive, umbrella, basket, or platform clinical trials is highly desirable.
Deep expertise in inflammatory bowel disease and/or other immune-mediated inflammatory disorders strongly preferred.
Significant experience with global regulatory interactions and submissions, including INDs, CTAs, briefing documents for global regulatory agencies.
Demonstrated willingness and ability to remain personally engaged in study-level execution while simultaneously providing strategic leadership.
Strong understanding of clinical trial design, biostatistics, translational medicine, drug development, and global regulatory requirements.

Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
Provide strategic leadership and medical expertise for the clinical development of our cutting-edge antibody portfolio in IBD.
Personally contribute to protocol development, medical review, safety assessment, data interpretation, and study-level decision making for ongoing and future IBD clinical trials.
Support the efforts of the medical monitoring team which ensures timely responses to investigative sites, provides medical safety oversight, and supports the collection of high-quality, clinically robust data.

Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients.
Contribute broadly to corporate strategy, organizational planning, and leadership initiatives.
Other duties as assigned.
Ensure development programs are conducted in compliance with global regulatory requirements and industry best practices.

This listing is sourced directly from Spyre Therapeutics's careers page and normalized into a canonical job model.