Genentech
Scientist 3, Induced Proximity Pharmacology, Discovery Oncology
South San Francisco
Sponsorship not specified$103k-$192kDetected 7 days ago
Machine LearningPharmacologyBioinformaticsCRISPRMolecular BiologyCell CultureResearchCommunicationProblem Solving
About the role
- Deploy and innovate on a diverse toolkit for measuring protein-protein and protein-small molecule interactions in cells (proximity labeling, FRET, BRET, and emerging approaches).
- Present and discuss data in lab meetings, department forums, and cross-functional project teams.
- Foster a collaborative culture by sharing expertise, learning from others, and staying current with the literature in a fast-moving field.
Responsibilities
- Design and execute creative, hypothesis-driven experiments to discover and validate novel oncology targets and proximity-based mechanisms of action that go beyond inhibition or degradation.
- Pioneer the design and implementation of induced proximity strategies to modulate protein function in cancer cells-reshaping signaling, localization, complex formation, and activity in ways that create new therapeutic openings.
- Develop and test bold therapeutic hypotheses, identify robust pharmacodynamic markers, and establish practical strategies to drug the targets you uncover.
- Engineer cancer cell systems to build the cellular models needed to interrogate proximity pharmacology.
- Collaborate with outstanding scientists across Genentech, including colleagues in Genomics, Transcriptomics, Proteomics, and Computational Sciences-and leverage rapidly evolving capabilities in AI/ML, proteomics, and functional genomics.
Requirements
- At least 3 years of research experience in an academic or industry laboratory.
- A creative and rigorous experimentalist with a proven track record of impactful research, demonstrated through publications.
- Cancer cell culture expertise, including experience establishing and maintaining difficult-to-culture cell lines.
- Cell line engineering expertise spanning lentiviral delivery, transposon-based gene insertion, and CRISPR knock-in approaches.
- Proficiency in a broad range of biochemical, molecular, and cell biology techniques including flow cytometry.
Nice to have
- Training and a strong research record in chemical biology.
- Strong background in cancer cell signaling pathways.
- Experience in functional genomics, including work with barcoded/pooled libraries.
- Direct experience with induced proximity modalities (e.g., PROTACs/molecular glues and related approaches), or a demonstrated interest in extending proximity pharmacology to novel functional outcomes.
Compensation
- The expected salary range for this position based on the primary location of California is $103,400 - $192,000.
Equal opportunity
- equal opportunity employer.
- If you have a disability and need an accommodation in relation to the online
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This listing is sourced directly from Genentech's careers page and normalized into a canonical job model.