Medra

Medra

Scientist, Biophysical Characterization (SPR/BLI)

San Francisco · Mid

Sponsorship not specifiedDetected 80 days ago
PythonData AnalysisRoboticsResearchMass Spectrometry

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odds of building a lasting career here

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Cap-exempt (no lottery)0
Sponsors this role80
Entry-level history0
PERM / green-card track0
Lottery odds40
Fits your clock70

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Files H-1B transfers

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About the role

  • We are looking for a Scientist to own biophysical characterization on the Medra Physical AI platform.
  • You will develop, validate, and scale label-free binding assays - primarily SPR and BLI - and turn them into robust, high-throughput workflows that run autonomously for our customers.
  • Antibody affinity and kinetics, epitope binning, self-interaction, and quantitation are the daily bread of this role, and you'll be responsible for making these assays reproducible, automation-ready, and reliable at a throughput and consistency that manual benchwork can't match.

Responsibilities

  • Develop, validate, and run SPR and BLI assays across the full range of formats - affinity and kinetics, epitope binning, self-interaction (AC-SINS and BLI-based), and concentration/quantitation - on platforms including the Carterra LSA and Gator BLI
  • Design assay strategies for antibody and alternative binder characterization, selecting the right sensor chemistry, capture approach, regeneration conditions, and analysis models for each target and format
  • Build out new biophysical capabilities end-to-end: scope the need, evaluate technologies, qualify instruments, write SOPs, and prepare validated workflows for autonomous execution
  • Partner with roboticists and software engineers to translate manual SPR/BLI workflows into reliable, high-throughput autonomous protocols - including sample handling, plate setup, sensor/chip management, and data pipeline integration
  • Develop rigorous data analysis and QC frameworks for kinetics fitting, binning heatmaps, and developability flags, and interpret results to inform customer go/no-go decisions
  • Maintain rigorous experimental records in electronic lab notebooks (ELN) and drive reproducibility across every assay you deploy
  • Demonstrated experience developing and qualifying biophysical assays from scratch, including method validation and troubleshooting

Requirements

  • Hands-on experience with high-throughput SPR platforms (e.g., Carterra LSA) and array-based epitope binning
  • Experience with alternative binder formats - VHHs, bispecifics, Fc-fusions, or non-Ig scaffolds
  • Hands-on experience with lab automation and liquid handling platforms (e.g., Lynx, Tempest, KingFisher)

Nice to have

  • We're a team of passionate, mission-driven engineers and scientists from companies like Tesla, Amazon, SpaceX, and Neuralink.
  • We're collaborative and love moving fast, both with our product and on team trips skiing or go-karting!
  • As a team, we love nerding out about engineering and robotics - plus other topics like race cars or cooking.
  • Our team is opinionated and straightforward.
  • If we have arguments or miscommunication, we resolve conflicts quickly and empathetically.

Benefits

  • Significant equity ownership
  • Medical insurance and dental insurance
  • We offer relocation benefits for applicants who need to relocate.

Company info

  • As a team, we love nerding out about engineering and robotics - plus other topics like race cars or cooking. We like learning new things and then sharing our new knowledge with each other.
  • Our team is opinionated and straightforward. We don't mind intense discussions about design tradeoffs. If we have arguments or miscommunication, we resolve conflicts quickly and empathetically.
  • Integrate biophysical data with orthogonal characterization - thermal stability (nanoDSF/DSC), aggregation and monomericity (HPLC-SEC/DLS), and polyspecificity - to give customers an integrated developability picture
  • Work directly with customers to scope characterization campaigns, communicate results clearly, and translate their scientific questions into executable assay plans

Visa & Work Authorization

  • l conditions), sexual orientation, gender identity, gender expression, age, marital status, military or veteran status, citizenship, or other characteristics protected by state, federal or local law or our other policies
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