Vertex Pharmaceuticals
Immunology Senior Research Scientist - Single-Cell Genomics
Seattle, WA · Senior
Sponsorship not specified$124k-$186kDetected 12 days ago
RecruitingBioinformaticsFlow CytometryMolecular BiologyNGSResearchCollaboration
About the role
- Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
- Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
- Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation.
Responsibilities
- Perform sample and library QC using standard methods such as Qubit, TapeStation, and Bioanalyzer
- Perform end-to-end single-cell genomics and multi-omics workflows, including emerging modalities such as multiome and CITE-seq where appropriate, from sample acquisition through library preparation and sequencing
- Optimize workflows as needed to maximize sample quality, cell recovery, and reproducibility across studies
- Support or interface with flow cytometry and cell sorting activities where needed to enable downstream genomics workflows
- Collaborate closely with bioinformatics and computational biology teams to support interpretation of complex datasets and enable biologically meaningful insights
- Perform critical evaluation of assay and sequencing metrics, including read depth, mapping performance, cell recovery, and QC thresholds
Requirements
- PhD in Genomics, Molecular Biology, Chemical Engineering, Bioengineering, or a related discipline with 2+ years of relevant experience
- Master's degree with 6+ years of relevant experience
Skills
- Deep hands-on expertise in single-cell genomics workflows, with particular experience in 10x Genomics platforms
- Strong wet-lab background in NGS library preparation, molecular biology, and complex sample processing
- Experience with downstream computational analysis of single-cell datasets is not required but would be considered a significant advantage
- Strong attention to detail and commitment to high standards in experimental rigor, data quality, and documentation
- Effective communicator and collaborative scientist who works well in multidisciplinary, matrixed research environments
- Education and Experience:
- PhD in Genomics, Molecular Biology, Chemical Engineering, Bioengineering, or a related discipline with 2+ years of relevant experience; or
- Master's degree with 6+ years of relevant experience; or
- Bachelor's degree with 8+ years of relevant experience
Compensation
- $124,200 - $186,400
- The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting.
- This role is eligible for an annual bonus and annual equity awards.
- Some roles may also be eligible for overtime pay, in accordance with federal and state requirements.
- Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
Benefits
- This role is eligible for an annual bonus and annual equity awards.
Company info
- The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.
- Company Information
- Vertex is a global biotechnology company that invests in scientific innovation.
- Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.
- Vertex is an E-Verify Employer in the United States.
- Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
- Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
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