Roche

Roche

Project Toxicologist

Philadelphia · Mid

Sponsorship not specified$150k-$195kDetected 7 days ago
PharmacologyCRISPRResearchProblem Solving

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odds of building a lasting career here

61Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role90
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.

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About the role

  • As a Regulatory/Project Toxicologist within our Department of Pharmacology and Toxicology, you will spearhead the nonclinical safety strategy for Roche innovative genetic medicine portfolio.
  • In this role, you will champion the safety evaluation of cutting-edge gene therapies-focusing on ocular- and CNS-directed programs-from early discovery through late-stage clinical development.
  • Communicate scientific findings and safety risk assessments clearly to internal governance committees and represent the organization in meetings with global health authorities.

Responsibilities

  • You will collaborate with world-class multidisciplinary scientists, driving decisions that safely accelerate groundbreaking medicines to patients.
  • Formulate, design, and direct integrated nonclinical safety and toxicology strategies (GLP and non-GLP) to support program progression and key regulatory milestones.
  • Lead proactive safety risk identification and design investigative mechanistic studies to evaluate and mitigate treatment-related toxicities.
  • A healthier future drives us to innovate.
  • Let's build a healthier future, together.
  • Serve as the nonclinical safety lead and primary toxicology representative on cross-functional drug development project teams across discovery, pre-clinical, and clinical stages.
  • Partner cross-functionally with Research Leads, Clinical, Regulatory, CMC, and external CROs to coordinate study execution, review protocols, and interpret complex safety data.
  • Author and review comprehensive nonclinical safety documentation, high-level regulatory filings (e.g., INDs, CTAs, PIPs, BLAs, GMO applications), and clinical documents (Investigator Brochures, ICFs).
  • You possess demonstrated experience in designing, executing, and interpreting robust nonclinical safety studies (GLP and non-GLP) that drive scientific and portfolio decisions.
  • Proven ability to manage multiple complex safety programs simultaneously while driving collaborative relationships with CRO partners and academic collaborators.

Requirements

  • You bring a minimum of 2-3 years of relevant toxicology experience within the biopharmaceutical, biotechnology, or contract research (CRO) industry.
  • You are an exceptional communicator and collaborator, recognized for critical data interpretation, complex scientific problem-solving, and cross-functional leadership.
  • Direct experience with genetic medicines, viral vectors (particularly AAVs), gene editing platforms, or novel RNA/oligonucleotide modalities.
  • Prior experience with ocular- or central nervous system (CNS)-targeted drug delivery or therapeutic development.

Compensation

  • The expected salary range for this position based on the primary location of Philadelphia is $149,900 to $194,900 Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitte

Benefits

  • Relocation benefits are available for this job posting.
  • Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come.
  • We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.
  • Demonstrated track record of authoring nonclinical regulatory modules for global health authority dossiers (IND/CTA) and participating in health authority interactions.

Company info

  • Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products.
  • Roche is an equal opportunity employer.
  • It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence.
  • The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
  • If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Equal opportunity

  • equal opportunity employer.
  • If you have a disability and need an accommodation in relation to the online
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