Parabilis Medicines

Scientist I, De Novo Discovery and Screening

Cambridge

Sponsorship not specified$110k-$130kDetected 16 days ago

Node.jsData AnalysisData SciencePCRMolecular BiologyCommunicationOrganizational Skills

About the role

The company has pioneered a new class of alpha-helical peptides - Helicons™ - capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines.
Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications.
Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact.

Design, execute, and troubleshoot phage display and mRNA display high-throughput screening campaigns to discover novel binders against challenging protein targets.
Design, construct, and produce diverse phage and mRNA display libraries using standard and advanced molecular biology techniques, including PCR, cloning, and in vitro transcription/translation workflows.
Perform and optimize display selections, including library amplification, enrichment, and downstream characterization of hits.
Evaluate and implement new technologies, workflows, and process improvements, with a particular focus on enhancing the performance, robustness, and scalability of the mRNA display platform.
Collaborate closely with cross-functional teams, including data science, biochemistry, and assay development, to advance discovery programs.
Demonstrated ability to design and execute experiments independently, troubleshoot effectively, and interpret complex datasets.
Excellent organizational skills, attention to detail, and ability to manage multiple priorities in a fast-paced environment.
30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com

Collaborative mindset with a high degree of initiative, curiosity, and enthusiasm for platform innovation and drug discovery.

familiarity with display technologies (phage, yeast, ribosome, or mRNA display) is plus.
Experience with high-throughput screening workflows and laboratory automation is preferred.
Strong biochemical and screening experience

The base salary range for this position is $110,000-$130,000, depending on experience, qualifications, and internal practices.
Parabilis's total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees' overall well-being.

We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to
We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences.

This listing is sourced directly from Parabilis Medicines's careers page and normalized into a canonical job model.