Nurix Therapeutics
Director, Pharmaceutical Development
Brisbane, CA · Director
Stay score
odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
$31,538 more — $249,538 — moves this role to Level III and 3 lottery entries. That figure is inside the range the employer already advertised.
Based on the DOL prevailing wage for this occupation and worksite, a base salary of $249,538 would place this position at wage Level III. That figure is within the posted range, and I'd like to target it. This role classifies under "Natural Sciences Managers" for prevailing-wage purposes.
DOL prevailing wage, 2026-27 wage year · Natural Sciences Managers (11-9121) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
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About the role
- Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease.
- Position: Nurix Therapeutics, Inc. is seeking a highly experienced Director of Pharmaceutical Development.
- span QbD-based formulation and process development from early phase through commercial launch.
Responsibilities
- Lead QbD-based formulation and process development for small molecule drug programs with a focus on oral and topical dosage forms across all development phases.
- Define and document the Quality Target Product Profile (QTPP) and identify Critical Quality Attributes (CQAs) to guide formulation strategy.
- Develop and optimize manufacturing processes appropriate to the dosage form, ensuring scalability and process robustness.
- Lead manufacturing scale-up activities from laboratory to pilot and commercial scale, ensuring robust and reproducible processes.
- drive root cause analysis and implement corrective actions.
- Drive late-stage development activities (Phase 2b through commercial launch) including clinical supply manufacturing, process performance qualification (PPQ), and continued process verification (CPV).
- Troubleshoot manufacturing deviations, out-of-specification results, and process failures; drive root cause analysis and implement corrective actions.
- Manage external CDMO partnerships, including vendor qualification, technical oversight, and performance governance to ensure project timelines, quality standards, and budget commitments are met.
Requirements
- 12+ years of progressive pharmaceutical development experience in an industry setting (biotechnology, pharmaceutical, or CDMO).
- Comprehensive hands-on experience with QbD methodologies: QTPP definition, CQA identification, CMA/CPP risk assessment, DoE, design space development, and control strategy establishment.
- Significant late-stage development experience (Phase 2b/3 and NDA/MAA submission) is required.
- Proven track record of authoring and/or reviewing CMC regulatory submissions (INDs, NDAs, CTDs) and successfully responding to agency queries.
- Knowledge of lifecycle management, post-approval changes, and SUPAC guidance.
- occasional GMP manufacturing facility access required.
- Approximately 25% travel required, including domestic and international trips to CDMO sites, clinical manufacturing sites, regulatory agency meetings, and scientific conferences.
- Must be able to gown for cleanroom/GMP environments
Nice to have
- Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Chemical Engineering, Chemistry, or a closely related discipline strongly preferred with 12 years of industry experience.
Compensation
- $218,000 - 260,000
This listing is sourced directly from Nurix Therapeutics's careers page and normalized into a canonical job model.