LatchBio
Bioinformatics Engineer - Variant
San Francisco or Remote · Mid · Full-time
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About the role
- Your work directly impacts how LLMs reason through genomic problems.
- choosing datasets, defining failure modes, writing grading scripts, and shipping evaluations that measure real capability.
Responsibilities
- You'll design, build, and evaluate LLM benchmarks for genomic analysis - spanning read alignment, assembly, variant calling, GWAS, causal inference, and multiomics integration.
- You'll own the full evaluation pipeline: choosing datasets, defining failure modes, writing grading scripts, and shipping evaluations that measure real capability. Your work directly impacts how LLMs reason through genomic problems.
- You'll own the full evaluation pipeline: choosing datasets, defining failure modes, writing grading scripts, and shipping evaluations that measure real capability.
- You'll own the full evaluation pipeline:
Requirements
- 3-5 years of hands-on research experience analyzing genomics datasets (especially human data), demonstrated through publications or industry work
- Deep expertise in at least one of: population genetics, statistical genetics, clinical genomics
- Candidates with all of the above qualifications + proven management skills will be eligible for more senior positions
Nice to have
- Familiarity with LLM-powered tools, prompting, or evaluation frameworks
- Background in cross-trait analysis or multiomics integration
- We care most about hard work and output.
- We're respectfully opinionated, it will always be us against problems, not each other.
- Waterfront office near Oracle Park, 2x free daily meals, unlimited snacks, company outings most months, and team offsites.
- Plus a vibrant community: cycling, soccer, figure skating, boxing, run clubs, reading clubs, martial arts, music, game nights.
- Compensation & Logistics
- 1099 (or W8-BEN) contract, 40 hrs/week, no end date
Compensation
- Compensation & Logistics
Visa & Work Authorization
- OPT visa holders only (not STEM Extension)
This listing is sourced directly from LatchBio's careers page and normalized into a canonical job model.