Legend Biotech US
Sr. Scientist, Lentivirus Upstream Processing
Somerset, New Jersey, United States · Senior · Full-time
No sponsorship$127k-$167kDetected 1 day ago
Project ManagementGMPCell CultureCommunicationCollaborationProblem Solving
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PERM / green-card track0
Lottery odds (Level III)83
Fits your clock70
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About the role
- The Senior Scientist, Lentivirus Upstream Process Development, will be a core technical contributor responsible for designing, executing, and optimizing upstream production processes for lentiviral vectors (LVV) within our innovative pipeline.
Responsibilities
- Design and execute experimental strategies for lentiviral vector upstream production.
- Perform development and optimization of upstream processes, including seed train expansion, suspension mammalian cell culture (HEK293/HEK293T), plasmid transient transfection optimization, and feed batch/perfusion bioprocessing in stir-tank and rocker bioreactors.
- Support the establishment and validation of bioreactor scale-up and scale-down models to ensure process comparability and predictability.
- Support the translation of bench-scale processes to GMP manufacturing, assisting in technology transfer and providing troubleshooting support during clinical production runs.
- maintain accurate documentation for USP data.
- Communicate technical findings, issues, and potential delays to project leads in a timely manner.
- Collaborate with cross-functional team members, including CMC Project Management and other technical leads, to support project goals.
- Apply scientific knowledge and technology to optimize vector titer, specific productivity, and quality.
- Support team activities by providing technical guidance to junior staff, fostering a culture of scientific rigor and continuous improvement.
- Author and review technical documents, including development reports, SOPs, and relevant sections for regulatory submissions (IND).
Requirements
- Demonstrated proficiency in developing and implementing bioreactor scale-up and scale-down models.
- Direct experience with cell and lentiviral vector technologies within the current emerging field.
- Applicants must be authorized to work in the United States.
- If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law.
Nice to have
- Advanced degree (PhD preferred, or MS) in Chemical Engineering, Bioengineering, or a related field.
- Hands-on experience in mammalian cell culture (HEK293, HEK293T), seed train expansion, feeding strategy, and transient transfection optimization specifically for viral vectors (Lentivirus preferred).
- Preferred experience in handling large-scale (>50L, e.g., 200L/500L) upstream bioreactor processes.
- Mandarin is a plus.
Skills
- Work closely with Downstream Process Development and Analytical Development teams to ensure integrated process outcomes.
- Ensure compliance with all internal and regulatory requirements.
Compensation
- $127,313 - $167,099 USD
Benefits
- Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one.
- These benefits are offered exclusively to permanent full-time employees.
- Contractors are not eligible for benefits through Legend Biotech.
Company info
- Scientist, Lentivirus Upstream Processing as part of the Technical Development team based in Somerset, NJ.
- We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays.
- As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program.
- We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.
Visa & Work Authorization
- Work Authorization & Employment Eligibility
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