Nurix Therapeutics

Research Associate II/III– Bioanalytical/In Vitro ADME/DMPK

Brisbane, CA · Mid

Sponsorship not specified$93k-$107kDetected 3 days ago

Patient CareResearchMass SpectrometryAnimal StudiesCommunication

About the role

Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease.
Position Nurix Therapeutics is searching for a motivated Research Associate to join our Bioanalytical-In Vitro DMPK team.
The primary responsibilities will be to conduct bioanalysis for in vivo samples and to conduct in vitro experiments.

Provide bioanalytical support for in-house PK, non-GLP safety TK
Conduct bioanalytical method development and qualification to support drug, metabolite and biomarker analysis
Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples
Perform metabolic identification (MetID) using LC-QTOF MS/MS, including accurate mass analysis, fragment interpretation and biotransformation pathway assignment
Independently operate, troubleshoot and maintain LC-MS/MS systems
Participate in multidisciplinary project teams and collaborate with other departments to understand bioanalytical needs for both PK and PD support
Manage projects conducted at CROs to ensure high quality bioanalytical data is delivered to meet project timelines
Maintain accurate and detailed scientific electronic laboratory notebooks
Perform all duties in keeping with the Company's core values, policies and all applicable regulations
Provide sample analysis to support PK, PK/PD, PK/efficacy, distribution, metabolism, and non-GLP toxicology studies

Conduct in-vitro stability assays to understand metabolism of drugs
Experience with H/UPLC and mass spectrometry
Good working knowledge of SCIEX LC-MS/MS systems for small molecule quantitation
PK analysis using Phoenix or other data management software
Management experience with CROs for outsourcing BA activities is preferred
Excellent oral and written communication skills
BS or master's with >4 years' experience working in a discovery setting using LC-MS/MS within a pharmaceutical/biotechnology company
Broad experience in small molecule drug candidate bioanalytical assay development/sample analysis in different biological matrices using LC-MS/MS

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package.

This listing is sourced directly from Nurix Therapeutics's careers page and normalized into a canonical job model.