Vertex Pharmaceuticals
Heme, Research Fellow
Boston, MA · Senior
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odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.
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DOL prevailing wage, 2026-27 wage year · Medical Scientists, Except Epidemiologists (19-1042) · Boston-Cambridge-Newton, MA-NH. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
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About the role
- The primary focus is to advance in vivo gene editing programs from preclinical proof-of-concept through IND-enabling studies and into Phase 1/2 trials.
- This leader will bridge clinical expertise with translational science to shape disease strategy, direct preclinical and translational research, and define the path to first-in-human studies.
- Serve as a physician-scientist leader for IND-enabling strategy in partnership with development, regulatory, and clinical teams
Responsibilities
- Lead scientific strategy for in vivo gene editing platforms, including editing technologies, delivery approaches, tissue targeting, and integrated pharmacology/toxicology
- Provide disease and mechanistic insight to support target selection, hypothesis testing, and candidate optimization
- Design and guide in vitro, ex vivo, and in vivo studies tied to clinically meaningful biology
- Lead cross-functional project teams to set goals, priorities, timelines, budgets, and decision points
- Integrate scientific, translational, and clinical considerations to drive programs toward development candidate nomination
- Help build a strong, collaborative, high-performing research culture
Requirements
- MD and/or PhD in a relevant discipline with 11+ years in academic medicine, translational research, biotech, pharma R&D, or related settings
- Strong expertise in drug development, translational science, and disease biology
- Demonstrated scientific leadership, publication record, and ability to influence project direction
- Experience in cell and gene therapy, genome editing, or in vivo pharmacology
- Track record in hemoglobinopathies, translational therapeutics, gene therapy, gene editing, stem cell biology, or related fields
- Direct experience in hemoglobinopathies (e.g., sickle cell disease, thalassemia, erythropoiesis, globin regulation)
- Experience with IND-enabling programs and translation to first-in-human strategy
- Familiarity with delivery systems, editing efficiency, durability, tissue specificity, and off-target risk
- Knowledge of HSC biology, stem cell phenotyping, engraftment, and ex vivo manipulation
- Experience with conditioning strategies for cell/gene therapy or transplantation
Nice to have
- Preferred Experience
Compensation
- $197,400 - $296,200
- The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting.
- This role is eligible for an annual bonus and annual equity awards.
- Some roles may also be eligible for overtime pay, in accordance with federal and state requirements.
- Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
Company info
- We are seeking an innovative physician-scientist to lead drug discovery and translational research within the Hemoglobinopathies Research Group.
Equal opportunity
- Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
This listing is sourced directly from Vertex Pharmaceuticals's careers page and normalized into a canonical job model.