Atavistik Bio
Senior Scientist, DMPK
Cambridge, MA · Senior
Sponsorship not specified$130k-$150kDetected 77 days ago
Computer VisionPharmacologyMass SpectrometryAnimal StudiesAnimal ModelsCommunicationOrganizational Skills
About the role
- We are seeking a Senior Scientist, DMPK, to join our R&D group and work with an enthusiastic team of highly skilled scientists in a fast-pace environment.
- This is a great opportunity to contribute to an efficient DMPK function while being part of an exciting early-stage company.
Responsibilities
- Manage consultants and vendors to support DMPK studies.
- Partner with the discovery group to optimize preclinical models and inform on first in human clinical dosing strategies.
- Lead and oversee in-vitro ADME/DMPK assays (metabolic stability, CYP, PPB, permeability, solubility).
- Support and interpret in-vivo PK and bioanalytical data (LC-MS/MS) and work collaboratively with the pharmacology leads to understand the PK/PD/Efficacy relationships.
- Develop DMPK strategies for hit-to-lead and lead optimization programs and inform on first in human clinical dosing strategies.
- Interface with CROs and external partners when needed.
- Collaborate cross functionally with all relevant areas to support strategic objectives.
- Reporting to the Senior Director, DMPK, this individual will be responsible for the design, execution, reviewing and interpreting the non-clinical DMPK data.
Requirements
- 5+ years of experience in bio/pharmaceutical industry, combined with drug development.
- Expertise in SAR analysis and IVIVC.
- Expertise managing CROs, GLP and other regulated activities.
- Ability to operate objectively and independently as a leader and as a member of a team.
Nice to have
- Experience with regulatory submissions for small molecules with a focus on preclinical is a plus.
- Experience in nonclinical toxicology is a plus.
Compensation
- Benefits: Atavistik Bio offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account
Company info
- Atavistik Bio is a privately-held clinical stage biotechnology company accelerating the discovery and development of transformative precision allosteric therapeutics to address serious unmet patient needs.
- Our proprietary AMPS™ platform allows us to rapidly unlock functional cryptic pockets across a broad range of target classes to accelerate the development of groundbreaking medicines.
- We have rapidly established an emerging pipeline of allosteric therapeutics with the potential to achieve superior efficacy and tolerability profiles by leveraging the power of allostery.
- Atavistik Bio is led by an experienced team of drug hunters with a proven track record of developing marketed small molecule therapies and supported by top-tier investors, including The Column Group, Nextech Invest, Lux Capital, Regeneron Ventures, and RA Capital Management.
Equal opportunity
- equal opportunity employer.
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