Twenty Twenty Therapeutics

Twenty Twenty Therapeutics

Staff / Principal Backend Software Engineer

Arlington, VA · Principal · Full-time

Sponsorship not specifiedDetected 327 days ago
PythonJavaGoRustC++C#KotlinDistributed SystemsBackend DevelopmentCode ReviewPostgreSQLMySQLAWSDockerKubernetesCI/CDGraphQLMachine LearningCybersecurityIncident ResponseRoadmappingLeadershipCommunicationMentoring

About the role

  • ABOUT THE COMPANY America is under sustained cyber attack.
  • Our adversaries infiltrate our networks, steal our IP, and degrade the digital infrastructure that modern life runs on.
  • They've learned-correctly-that those attacks rarely produce consequences.

Responsibilities

  • Architect and build high-throughput backend services that process real-time operational data.
  • Lead technical design reviews and choose pragmatic approaches for new features and system improvements.
  • Design event-driven and distributed systems that are resilient, observable, and performance-tuned.
  • Build and maintain CI/CD workflows that enable rapid, secure delivery.
  • Troubleshoot complex production issues, lead incident response, and drive durable fixes.
  • Partner with product and operational stakeholders to translate needs into deliverable technical plans.
  • Support hiring by participating in interviews and helping define what "great" looks like.

Requirements

  • You enjoy mentoring and leveling up engineers through feedback, pairing, and strong technical direction.
  • 4+ years of experience in Golang, or 4+ years writing server-side business logic in an object-oriented language (Java, Kotlin, C#, Python) or systems language (C, C++, Rust) with strong system design aptitude.
  • You have led technical initiatives end-to-end, including architecture, execution, and delivery.
  • You have experience designing distributed systems (e.g., event-driven architectures, messaging, consistency tradeoffs).
  • You have a track record mentoring engineers through code reviews, technical guidance, and feedback.
  • You have strong communication skills and can align teams around clear technical decisions.

Nice to have

  • You have experience designing data models and queries in graph databases (e.g., Neo4j, AWS Neptune).
  • You have used relational databases (ex: Postgres, MySQL, or MariaDB) to solve business problems and are able to reason about query performance.
  • You've worked on defense, intelligence, or security-focused products with real operational users.
  • You've shipped large-scale data processing systems (streaming, near-real-time analytics, or similar).
  • You've integrated ML/AI capabilities into production systems in a practical, measurable way.
  • You have open-source contributions or personal projects that demonstrate strong engineering craft.
  • Go (Golang) business logic
  • Event-driven messaging (e.g., NATS)

Benefits

  • We consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, veteran status, disability, or any other protected status.
  • Medical, dental, and vision plan options.
  • Life / AD&D, disability coverage options.
  • Paid parental leave for eligible full-time employees.
  • Paid holidays and flexible PTO.
  • HSA/FSA options, dependent care FSA.
  • Commuter benefits.
  • Building fitness center.
  • Desk setup stipend.
  • Benefits vary by location, role, and eligibility.

Company info

  • America is under sustained cyber attack.
  • Twenty was founded to change that, by making our adversaries think twice before they attack us.
  • Our vision is American and allied primacy in cyberspace-a future where they cannot contest us, deterrence is assured, and the free world remains secure.
  • Founded in 2024, Twenty Technologies (www.twenty.io http://www.twenty.io) industrializes offensive cyber operations for the U.S. and its allies.
  • Headquartered in Arlington, Virginia, Twenty has raised $138M from Accel, Caffeinated Capital, Friends & Family Capital, Point72 Ventures, General Catalyst, and In-Q-Tel.
  • You'll design and build backend systems that turn real-time operational data into mission-critical capabilities.
  • This role owns core services that need to be fast, reliable, and secure-operating across cloud and on-prem environments.
  • You'll make high-leverage architecture decisions, drive technical execution, and raise the bar through mentorship and engineering standards.
  • You'll partner closely with product, operations, and frontend teams to ship systems that work under real-world constraints.

Equal opportunity

  • equal opportunity employer.
  • If you need a reasonable accommodation during the hiring process, let us know and we will work with you.

Visa & Work Authorization

  • Government security clearance
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This listing is sourced directly from Twenty Twenty Therapeutics's careers page and normalized into a canonical job model.