Tango Therapeutics
Senior Director, Clinical Development
Boston, MA · Director
Sponsorship not specifiedDetected 23 days ago
GCPClinical TrialsPharmacologyFDA RegulatoryMolecular BiologyPharmacovigilanceResearchLeadershipCommunicationProblem SolvingPublic SpeakingRegulatory Affairs
About the role
- Provide leadership to the clinical team and serve as the medical and scientific expert for development programs
- Act as Medical Monitor and/or oversee external Medical Monitors for company-sponsored clinical trials, ensuring appropriate medical oversight and patient safety
- Provide strategic oversight of adverse event review, safety monitoring, protocol compliance, and clinical data evaluation
Responsibilities
- Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
- The Senior Director will build and maintain strong relationships with investigators, key opinion leaders (KOLs), and external partners while ensuring the successful execution of clinical studies and overall program objectives.
- Lead the clinical development strategy and execution for assigned clinical-stage oncology asset(s), partnering with cross-functional teams to create and implement comprehensive clinical development plans
- Serve as the primary clinical lead for study investigators and key opinion leaders, building strong relationships that support program success and scientific advancement
Requirements
- 5+ years of clinical development experience within the biotechnology and/or pharmaceutical industry, including experience leading oncology development programs
- Strong understanding of the biological and translational sciences underlying modern oncology drug development, including molecular biology, cancer genetics, immunology, and precision medicine approaches
- Excellent strategic thinking, organizational, and project leadership skills, with the ability to balance high-level planning and hands-on execution
- Strong problem-solving skills and the ability to identify innovative approaches to advance development programs and organizational objectives
- Exceptional communication and presentation skills, including the ability to engage effectively with senior leadership, investig
- Perform additional responsibilities as required to support the advancement of Tango's clinical programs
- MD required; board certification or board eligibility in Medical Oncology, Hematology/Oncology, or a related specialty strongly preferred
- Demonstrated experience in the design, execution, interpretation, and reporting of oncology clinical trials involving targeted therapies, small molecules, and/or immuno-oncology agents
- Experience supporting or leading late-stage clinical development programs, NDA/BLA/MAA submissions, and Health Authority interactions
- Proven ability to lead and influence cross-functional teams within a matrixed organization
Benefits
- Lead clinical contributions to regulatory submissions, including INDs, CTAs, NDA/MAA filings, and interactions with Health Authorities
- Lead responses to questions from Health Authorities, Ethics Committees, and Institutional Review Boards, ensuring consistency and scientific rigor
- The Senior Director, Clinical Development will provide medical and scientific leadership for Tango's oncology development programs, driving clinical strategy from early-stage development through registration.
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